PER3

PER3
Identifiers
Aliases	PER3, GIG13, FASPS3, period circadian clock 3
External IDs	OMIM: 603427 MGI: 1277134 HomoloGene: 7886 GeneCards: PER3
Gene ontology Molecular function • ubiquitin protein ligase binding • kinase binding • protein binding Cellular component • cytoplasm • nucleus Biological process • circadian rhythm • circadian regulation of gene expression • rhythmic process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of circadian sleep/wake cycle, sleep • protein stabilization • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8863	18628
Ensembl	ENSG00000049246	ENSMUSG00000028957
UniProt	P56645	O70361
RefSeq (mRNA)	NM_001289861 NM_001289862 NM_001289863 NM_001289864 NM_016831	NM_011067 NM_001289877 NM_001289878
RefSeq (protein)	NP_001276790.1 NP_001276791.1 NP_001276792.1 NP_001276793.1 NP_058515.1	NP_035197.2
Location (UCSC)	Chr 1: 7.78 – 7.85 Mb	Chr 4: 151 – 151.04 Mb
PubMed search	[1]	[2]
Wikidata

The PER3 gene encodes the period circadian protein homolog 3 protein in humans.^[3]

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.^[4]

See also

• PER1
• PER2

References

Further reading

External links

• PER3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.