IL13RA2
| IL13RA2 | |||||||||||||||||
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| Aliases | IL13RA2, CD213A2, CT19, IL-13R, IL13BP, interleukin 13 receptor subunit alpha 2 | ||||||||||||||||
| External IDs | MGI: 1277954 HomoloGene: 534 GeneCards: IL13RA2 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr X: 115 – 115.02 Mb | Chr X: 147.38 – 147.43 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
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| View/Edit Human | View/Edit Mouse |
Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.[3]
Function
IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.[3]
See also
References
Further reading
- Andrews AL, Nasir T, Bucchieri F, et al. (1996). "IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts". J. Allergy Clin. Immunol. 118 (4): 858–65. doi:10.1016/j.jaci.2006.06.041. PMID 17030238.
- Caput D, Laurent P, Kaghad M, et al. (1996). "Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain". J. Biol. Chem. 271 (28): 16921–6. doi:10.1074/jbc.271.28.16921. PMID 8663118.
- Zhang JG, Hilton DJ, Willson TA, et al. (1997). "Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains". J. Biol. Chem. 272 (14): 9474–80. doi:10.1074/jbc.272.14.9474. PMID 9083087.
- Gauchat JF, Schlagenhauf E, Feng NP, et al. (1997). "A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor". Eur. J. Immunol. 27 (4): 971–8. doi:10.1002/eji.1830270425. PMID 9130652.
- Guo J, Apiou F, Mellerin MP, et al. (1997). "Chromosome mapping and expression of the human interleukin-13 receptor". Genomics. 42 (1): 141–5. doi:10.1006/geno.1997.4628. PMID 9177784.
- Donaldson DD, Whitters MJ, Fitz LJ, et al. (1998). "The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1". J. Immunol. 161 (5): 2317–24. PMID 9725226.
- Osawa M, Miyoshi S, Copeland NG, et al. (2000). "Characterization of the mouse interleukin-13 receptor alpha1 gene". Immunogenetics. 51 (11): 974–81. doi:10.1007/s002510000225. PMID 11003391.
- Kawakami K, Takeshita F, Puri RK (2001). "Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain". J. Biol. Chem. 276 (27): 25114–20. doi:10.1074/jbc.M100936200. PMID 11352909.
- Daines MO, Hershey GK (2002). "A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma". J. Biol. Chem. 277 (12): 10387–93. doi:10.1074/jbc.M108109200. PMID 11786536.
- Okano F, Storkus WJ, Chambers WH, et al. (2002). "Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain". Clin. Cancer Res. 8 (9): 2851–5. PMID 12231526.
- Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, et al. (2003). "Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein". J. Invest. Dermatol. 119 (5): 1114–20. doi:10.1046/j.1523-1747.2002.19509.x. PMID 12445201.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241
. PMID 12477932. - David M, Bertoglio J, Pierre J (2003). "TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression". Ann. N. Y. Acad. Sci. 973: 207–9. doi:10.1111/j.1749-6632.2002.tb04633.x. PMID 12485861.
- Wu AH, Low WC (2003). "Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter". Neuro-oncology. 5 (3): 179–87. doi:10.1215/S1152-8517-02-00051-0. PMC 1920687. PMID 12816724.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Arima K, Sato K, Tanaka G, et al. (2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors". J. Biol. Chem. 280 (26): 24915–22. doi:10.1074/jbc.M502571200. PMID 15870068.
- Fichtner-Feigl S, Strober W, Kawakami K, et al. (2006). "IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis". Nat. Med. 12 (1): 99–106. doi:10.1038/nm1332. PMID 16327802.
- Daines MO, Tabata Y, Walker BA, et al. (2006). "Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling". J. Immunol. 176 (12): 7495–501. doi:10.4049/jimmunol.176.12.7495. PMID 16751396.
- Kioi M, Kawakami M, Shimamura T, et al. (2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer. 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988.
- Granel B, Allanore Y, Chevillard C, et al. (2007). "IL13RA2 gene polymorphisms are associated with systemic sclerosis". J. Rheumatol. 33 (10): 2015–9. PMID 16981293.
External links
- IL13RA2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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