Interleukin 32

IL32
Identifiers
Aliases IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, Interleukin 32, IL-32
External IDs HomoloGene: 128400 GeneCards: IL32
Orthologs
Species Human Mouse
Entrez

9235

n/a

Ensembl

ENSG00000008517

n/a

UniProt

P24001

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC) Chr 16: 3.07 – 3.08 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Interleukin 32 (Il32) is a protein that in humans is encoded by the IL32 gene.[2]

Function

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNF-alpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

Interleukin 32 (IL-32) is a pro-inflammatory cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and IL-6. In addition, it can also induce the production of chemokines such as IL-8 and MIP-2 / CXCL2.[3]

IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton.[4]

References

  1. ↑ "Human PubMed Reference:".
  2. 1 2 "Entrez Gene: Interleukin 32".
  3. ↑ Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA (January 2005). "Interleukin-32: a cytokine and inducer of TNFalpha". Immunity. 22 (1): 131–42. doi:10.1016/j.immuni.2004.12.003. PMID 15664165.
  4. ↑ Mabilleau G, Sabokbar A (2009). "Interleukin-32 promotes osteoclast differentiation but not osteoclast activation". PLoS ONE. 4 (1): e4173. doi:10.1371/journal.pone.0004173. PMC 2613539Freely accessible. PMID 19137064.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia - version of the 6/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.