CD37
| CD37 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | CD37, GP52-40, TSPAN26, CD37 molecule | ||||||||||||||||
| External IDs | OMIM: 151523 MGI: 88330 HomoloGene: 20422 GeneCards: CD37 | ||||||||||||||||
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| RNA expression pattern | |||||||||||||||||
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| Orthologs | |||||||||||||||||
| Species | Human | Mouse | |||||||||||||||
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| RefSeq (mRNA) | |||||||||||||||||
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| Location (UCSC) | Chr 19: 49.34 – 49.34 Mb | Chr 7: 45.23 – 45.24 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
| Wikidata | |||||||||||||||||
| View/Edit Human | View/Edit Mouse |
Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[3][4]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.[4]
See also
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Virtaneva KI, Angelisova P, Baumruker T, Horejsi V, Nevanlinna H, Schroder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics. 37 (6): 461–465. doi:10.1007/BF00222471. PMID 8436422.
- 1 2 "Entrez Gene: CD37 CD37 molecule".
Further reading
- Horejsí V, Vlcek C (1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Lett. 288 (1–2): 1–4. doi:10.1016/0014-5793(91)80988-F. PMID 1879540.
- Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
- Classon BJ, Williams AF, Willis AC, et al. (1990). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". J. Exp. Med. 172 (3): 1007–1007. doi:10.1084/jem.172.3.1007. PMC 2188538
. PMID 2388030. - Classon BJ, Williams AF, Willis AC, et al. (1989). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". J. Exp. Med. 169 (4): 1497–1502. doi:10.1084/jem.169.4.1497. PMC 2189247. PMID 2466944.
- Schwartz-Albiez R, Dörken B, Hofmann W, Moldenhauer G (1988). "The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein". J. Immunol. 140 (3): 905–14. PMID 3257508.
- Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins". Immunogenetics. 39 (4): 249–56. doi:10.1007/BF00188787. PMID 8119731.
- Wright MD, Rochelle JM, Tomlinson MG, et al. (1993). "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication". Int. Immunol. 5 (2): 209–216. doi:10.1093/intimm/5.2.209. PMID 8452817.
- Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
- Okochi H, Mine T, Nashiro K, et al. (1999). "Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract". J. Clin. Gastroenterol. 29 (1): 63–67. doi:10.1097/00004836-199907000-00016. PMID 10405235.
- Matsumoto K, Bochner BS, Wakiguchi H, Kurashige T (1999). "Functional expression of transmembrane 4 superfamily molecules on human eosinophils". Int. Arch. Allergy Immunol. 120 Suppl 1: 38–44. doi:10.1159/000053592. PMID 10529602.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- van Spriel AB, Puls KL, Sofi M, et al. (2004). "A regulatory role for CD37 in T cell proliferation". J. Immunol. 172 (5): 2953–61. doi:10.4049/jimmunol.172.5.2953. PMID 14978098.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Meyer-Wentrup F, Figdor CG, Ansems M, et al. (2007). "Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production". J. Immunol. 178 (1): 154–62. doi:10.4049/jimmunol.178.1.154. PMID 17182550.
- Zhao X, Lapalombella R, Joshi T, et al. (2007). "Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical". Blood. 110 (7): 2569–2577. doi:10.1182/blood-2006-12-062927. PMC 1988922. PMID 17440052.
External links
- CD37 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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