UBE2E1

UBE2E1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases UBE2E1, UBCH6, ubiquitin conjugating enzyme E2 E1
External IDs MGI: 107411 HomoloGene: 84372 GeneCards: UBE2E1
EC number 2.3.2.24
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

7324

22194

Ensembl

ENSG00000170142

ENSMUSG00000021774

UniProt

P51965

P52482

RefSeq (mRNA)

NM_001202476
NM_003341
NM_182666

NM_009455

RefSeq (protein)

NP_001189405.1
NP_003332.1
NP_872607.1
NP_003332.1

NP_033481.1

Location (UCSC) Chr 3: 23.81 – 23.89 Mb Chr 14: 18.28 – 18.33 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.[3][4]

Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[4]

Interactions

UBE2E1 has been shown to interact with Ataxin 1[5] and NEDD4.[6][7]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (Mar 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J. Biol. Chem. 271 (5): 2795–800. doi:10.1074/jbc.271.5.2795. PMID 8576257.
  4. 1 2 "Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)".
  5. ↑ Hong S, Lee S, Cho SG, Kang S (Jun 2008). "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1". Biochem. Biophys. Res. Commun. 371 (2): 256–60. doi:10.1016/j.bbrc.2008.04.066. PMID 18439907.
  6. ↑ Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509.
  7. ↑ Malakhova OA, Zhang DE (Apr 2008). "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response". J. Biol. Chem. 283 (14): 8783–7. doi:10.1074/jbc.C800030200. PMC 2276364Freely accessible. PMID 18287095.

Further reading

  • Pickart CM (2001). "Mechanisms underlying ubiquitination". Annu. Rev. Biochem. 70: 503–33. doi:10.1146/annurev.biochem.70.1.503. PMID 11395416. 
  • Chen P, Johnson P, Sommer T, Jentsch S, Hochstrasser M (1993). "Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor". Cell. 74 (2): 357–69. doi:10.1016/0092-8674(93)90426-Q. PMID 8393731. 
  • Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509. 
  • Nyman TA, Matikainen S, Sareneva T, Julkunen I, Kalkkinen N (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes". Eur. J. Biochem. 267 (13): 4011–9. doi:10.1046/j.1432-1327.2000.01433.x. PMID 10866800. 
  • Lenk U, Sommer T (2000). "Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization". J. Biol. Chem. 275 (50): 39403–10. doi:10.1074/jbc.M006949200. PMID 10991948. 
  • Pringa E, Martinez-Noel G, Muller U, Harbers K (2001). "Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes". J. Biol. Chem. 276 (22): 19617–23. doi:10.1074/jbc.M100192200. PMID 11274149. 
  • Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x. PMID 11322894. 
  • Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
  • Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H (2005). "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300. 


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