BIRC6
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Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.[3][4]
Function
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.[4]
Interactions
BIRC6 has been shown to interact with KIF23.[5]
Diseases
BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers [6] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology,[7]).
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun. 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019.
- 1 2 "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)".
- ↑ Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell. 132 (5): 832–45. doi:10.1016/j.cell.2008.01.012. PMID 18329369.
- ↑ http://atlasgeneticsoncology.org/Genes/BIRC6ID798ch2p22.html
- ↑ "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.
Further reading
- Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence." (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
- Qiu XB, Markant SL, Yuan J, Goldberg AL (2005). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMC 380992
. PMID 14765125. - Bartke T, Pohl C, Pyrowolakis G, Jentsch S (2005). "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.". Mol. Cell. 14 (6): 801–11. doi:10.1016/j.molcel.2004.05.018. PMID 15200957.
- Hao Y, Sekine K, Kawabata A, Nakamura H, Ishioka T, Ohata H, Katayama R, Hashimoto C, Zhang X, Noda T, Tsuruo T, Naito M (2004). "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function.". Nat. Cell Biol. 6 (9): 849–60. doi:10.1038/ncb1159. PMID 15300255.
- Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
- Qiu XB, Goldberg AL (2005). "The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9.". J. Biol. Chem. 280 (1): 174–82. doi:10.1074/jbc.M411430200. PMID 15507451.
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