PUM1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1IB2, 1M8W, 1M8X, 1M8Y, 1M8Z, 2YJY, 3BSB, 3BSX, 3Q0L, 3Q0M, 3Q0N, 3Q0O, 3Q0P

Identifiers

Aliases

PUM1, HSPUM, PUMH, PUMH1, PUML1, pumilio RNA binding family member 1

External IDs

MGI: 1931749 HomoloGene: 22830 GeneCards: PUM1

Gene ontology
Molecular function	• mRNA 3'-UTR binding • protein binding • RNA binding • poly(A) RNA binding
Cellular component	• cytoplasm • cytosol • P-body • cytoplasmic stress granule
Biological process	• regulation of gene silencing by miRNA • cell differentiation • regulation of mRNA stability • adult locomotory behavior • positive regulation of gene silencing by miRNA • stem cell differentiation • regulation of cell cycle • posttranscriptional gene silencing • regulation of chromosome segregation • positive regulation of RIG-I signaling pathway • mRNA destabilization • spermatogenesis • regulation of translation • posttranscriptional regulation of gene expression
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9698


80912

Ensembl


ENSG00000134644


n/a

UniProt


Q14671


Q80U78

RefSeq (mRNA)


NM_014676 NM_001020658


NM_001159603 NM_001159604 NM_001159605 NM_001159606 NM_030722

RefSeq (protein)


NP_001018494.1 NP_055491.1


NP_001153075.1 NP_001153076.1 NP_001153077.1 NP_001153078.1 NP_109647.2

Location (UCSC)

Chr 1: 30.93 – 31.07 Mb

Chr 4: 130.66 – 130.78 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene.^[3]

Function

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain composed of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.^[3]

References

Spassov DS, Jurecic R (2004). "The PUF family of RNA-binding proteins: does evolutionarily conserved structure equal conserved function?". IUBMB Life. 55 (7): 359–66. doi:10.1080/15216540310001603093. PMID 14584586.
Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wang X, Zamore PD, Hall TM (2001). "Crystal structure of a Pumilio homology domain". Mol. Cell. 7 (4): 855–65. doi:10.1016/S1097-2765(01)00229-5. PMID 11336708.
Wang X, McLachlan J, Zamore PD, Hall TM (2002). "Modular recognition of RNA by a human pumilio-homology domain". Cell. 110 (4): 501–12. doi:10.1016/S0092-8674(02)00873-5. PMID 12202039.
Spassov DS, Jurecic R (2003). "Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins". Gene. 299 (1–2): 195–204. doi:10.1016/S0378-1119(02)01060-0. PMID 12459267.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dazard JE, Gal H, Amariglio N, et al. (2003). "Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer". Oncogene. 22 (19): 2993–3006. doi:10.1038/sj.onc.1206537. PMID 12771951.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Jordanova A, Irobi J, Thomas FP, et al. (2006). "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy". Nat. Genet. 38 (2): 197–202. doi:10.1038/ng1727. PMID 16429158.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

1ib2: CRYSTAL STRUCTURE OF A PUMILIO-HOMOLOGY DOMAIN

1m8w: CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-19 RNA

1m8x: CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-14 RNA

1m8y: CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE2-10 RNA

1m8z: Crystal Structure Of A Pumilio-Homology Domain

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PUM1

Function

References

Further reading