PRKG1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1ZXA, 3OCP, 3OD0, 3OGJ, 4KU7, 4KU8, 4QX5, 4QXK, 4R4L, 4R4M, 4Z07

Identifiers

Aliases

PRKG1, 1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, protein kinase, cGMP-dependent, type I

External IDs

MGI: 108174 HomoloGene: 55964 GeneCards: PRKG1

Genetically Related Diseases

obesity, asthma^[1]

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein kinase activity • calcium channel regulator activity • cGMP binding • kinase activity • protein binding • catalytic activity • ATP binding • protein serine/threonine kinase activity • cGMP-dependent protein kinase activity
Cellular component	• cytoplasm • cytosol • Golgi apparatus • plasma membrane
Biological process	• negative regulation of smooth muscle contraction • phosphorylation • regulation of GTPase activity • dendrite development • neuron migration • negative regulation of platelet aggregation • cGMP-mediated signaling • protein phosphorylation • relaxation of vascular smooth muscle • forebrain development • metabolic process • actin cytoskeleton organization • signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5592


19091

Ensembl


ENSG00000185532


ENSMUSG00000052920

UniProt


Q13976


P0C605

RefSeq (mRNA)


NM_001098512 NM_006258


NM_001013833 NM_011160

RefSeq (protein)


NP_001091982.1 NP_006249.1


NP_001013855.1 NP_035290.1

Location (UCSC)

Chr 10: 50.99 – 52.3 Mb

Chr 19: 30.57 – 31.77 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.^[4]^[5]^[6]

Interactions

PRKG1 has been shown to interact with:

References

↑ "Diseases that are genetically associated with PRKG1 view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Sep 1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat". FEBS Letters. 255 (2): 321–9. doi:10.1016/0014-5793(89)81114-7. PMID 2792381.
↑ Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T (April 1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell Genetics. 59 (4): 270–3. doi:10.1159/000133267. PMID 1544322.
↑ "Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I".
↑ Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB (Aug 2002). "cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I". The Journal of Biological Chemistry. 277 (35): 32003–14. doi:10.1074/jbc.M112332200. PMID 12082086.
1 2 Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174.
↑ Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (Jun 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". The Journal of Biological Chemistry. 276 (26): 24153–9. doi:10.1074/jbc.M101530200. PMID 11309393.
↑ Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G (Dec 2003). "Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure". Nature Medicine. 9 (12): 1506–12. doi:10.1038/nm958. PMID 14608379.
↑ Yuasa K, Michibata H, Omori K, Yanaka N (Dec 1999). "A novel interaction of cGMP-dependent protein kinase I with troponin T". The Journal of Biological Chemistry. 274 (52): 37429–34. doi:10.1074/jbc.274.52.37429. PMID 10601315.

Picciotto MR, Cohn JA, Bertuzzi G, Greengard P, Nairn AC (Jun 1992). "Phosphorylation of the cystic fibrosis transmembrane conductance regulator". The Journal of Biological Chemistry. 267 (18): 12742–52. PMID 1377674.
Thomas MK, Francis SH, Corbin JD (Sep 1990). "Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP". The Journal of Biological Chemistry. 265 (25): 14971–8. PMID 2168396.
Pöhler D, Butt E, Meissner J, Müller S, Lohse M, Walter U, Lohmann SM, Jarchau T (Nov 1995). "Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system". FEBS Letters. 374 (3): 419–25. doi:10.1016/0014-5793(95)01168-E. PMID 7589584.
Komalavilas P, Lincoln TM (Mar 1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry. 269 (12): 8701–7. PMID 8132598.
Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J, Walter U (May 1994). "cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets". The Journal of Biological Chemistry. 269 (20): 14509–17. PMID 8182057.
Suko J, Maurer-Fogy I, Plank B, Bertel O, Wyskovsky W, Hohenegger M, Hellmann G (Jan 1993). "Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase". Biochimica et Biophysica Acta. 1175 (2): 193–206. doi:10.1016/0167-4889(93)90023-I. PMID 8380342.
Tamura N, Itoh H, Ogawa Y, Nakagawa O, Harada M, Chun TH, Suga S, Yoshimasa T, Nakao K (Mar 1996). "cDNA cloning and gene expression of human type Ialpha cGMP-dependent protein kinase". Hypertension. 27 (3 Pt 2): 552–7. doi:10.1161/01.hyp.27.3.552. PMID 8613202.
Salih E, Zhou HY, Glimcher MJ (Jul 1996). "Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases". The Journal of Biological Chemistry. 271 (28): 16897–905. doi:10.1074/jbc.271.28.16897. PMID 8663267.
Xing J, Ginty DD, Greenberg ME (Aug 1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science. 273 (5277): 959–63. doi:10.1126/science.273.5277.959. PMID 8688081.
Orstavik S, Natarajan V, Taskén K, Jahnsen T, Sandberg M (Jun 1997). "Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1)". Genomics. 42 (2): 311–8. doi:10.1006/geno.1997.4743. PMID 9192852.
Deak M, Clifton AD, Lucocq LM, Alessi DR (Aug 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
Du K, Montminy M (Dec 1998). "CREB is a regulatory target for the protein kinase Akt/PKB". The Journal of Biological Chemistry. 273 (49): 32377–9. doi:10.1074/jbc.273.49.32377. PMID 9829964.
Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M (Mar 1999). "Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2467–72. doi:10.1073/pnas.96.5.2467. PMC 26808. PMID 10051666.
Wang X, Bruderer S, Rafi Z, Xue J, Milburn PJ, Krämer A, Robinson PJ (Aug 1999). "Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly". The EMBO Journal. 18 (16): 4549–59. doi:10.1093/emboj/18.16.4549. PMC 1171529. PMID 10449420.
Surks HK, Mochizuki N, Kasai Y, Georgescu SP, Tang KM, Ito M, Lincoln TM, Mendelsohn ME (Nov 1999). "Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha". Science. 286 (5444): 1583–7. doi:10.1126/science.286.5444.1583. PMID 10567269.
Yuasa K, Michibata H, Omori K, Yanaka N (Dec 1999). "A novel interaction of cGMP-dependent protein kinase I with troponin T". The Journal of Biological Chemistry. 274 (52): 37429–34. doi:10.1074/jbc.274.52.37429. PMID 10601315.
Yuasa K, Omori K, Yanaka N (Feb 2000). "Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha". The Journal of Biological Chemistry. 275 (7): 4897–905. doi:10.1074/jbc.275.7.4897. PMID 10671526.
Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD (Feb 2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle". The Journal of Biological Chemistry. 275 (8): 5504–11. doi:10.1074/jbc.275.8.5504. PMID 10681529.

Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated Mammalian target of rapamycin EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1

Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3

Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3

3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB

(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G

(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4

Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase

Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10

Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-

IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP

cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY

cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1

Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3

Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase

Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2

G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6

Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1

Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4

Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2

Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1

(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1

Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14

MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14

Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3

(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-

Tropomyosin kinase (EC 2.7.11.28)	-

Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-

Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

This article is issued from Wikipedia - version of the 7/30/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

PRKG1

Interactions

References

Further reading