DAPK1

DAPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IG1, 1JKK, 1JKL, 1JKS, 1JKT, 1P4F, 1WVX, 1WVY, 1YR5, 2W4J, 2W4K, 2X0G, 2XUU, 2XZS, 2Y0A, 2Y4P, 2Y4V, 2YAK, 3DFC, 3DGK, 3EH9, 3EHA, 3F5G, 3F5U, 3GU4, 3GU5, 3GU6, 3GU7, 3GU8, 3GUB, 3ZXT, 4B4L, 4PF4, 4TL0, 4TXC, 4UV0, 4YO4, 4YPD, 5AUW, 5AUU, 5AV1, 5AUY, 5AUT, 5AUX, 5AUV, 5AUZ, 5AV0, 5AV4, 5AV2, 5AV3
Identifiers
Aliases	DAPK1, DAPK, death associated protein kinase 1
External IDs	MGI: 1916885 HomoloGene: 3626 GeneCards: DAPK1
Genetically Related Diseases
smallpox, pancreatic cancer[1]
Targeted by Drug
staurosporine[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • GTP binding • syntaxin-1 binding • kinase activity • protein binding • identical protein binding • calmodulin-dependent protein kinase activity • protein serine/threonine kinase activity • calmodulin binding • ATP binding • protein kinase activity Cellular component • plasma membrane • actin cytoskeleton • cytoskeleton • cytoplasm Biological process • regulation of apoptotic process • negative regulation of translation • intracellular signal transduction • phosphorylation • negative regulation of apoptotic process • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of autophagy • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • cellular response to interferon-gamma • apoptotic signaling pathway • protein autophosphorylation • regulation of translation • extrinsic apoptotic signaling pathway via death domain receptors • signal transduction • apoptotic process • regulation of N-methyl-D-aspartate selective glutamate receptor activity • protein phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1612	69635
Ensembl	ENSG00000196730	ENSMUSG00000021559
UniProt	P53355	Q80YE7
RefSeq (mRNA)	NM_001288729 NM_001288730 NM_001288731 NM_004938	NM_001285917 NM_029653 NM_134062
RefSeq (protein)	NP_001275658.1 NP_001275659.1 NP_001275660.1 NP_004929.2	NP_001272846.1 NP_083929.2 NP_598823.1
Location (UCSC)	Chr 9: 87.5 – 87.71 Mb	Chr 13: 60.6 – 60.76 Mb
PubMed search	[3]	[4]
Wikidata

Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.^[5]

Function

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.^[6]

In melanocytic cells DAPK1 gene expression may be regulated by MITF.^[7]

As a drug target

Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers.^[8] This has not been demonstrated in actual patients.

References

Further reading

PDB gallery
1ig1: 1.8A X-Ray structure of ternary complex of a catalytic domain of death-associated protein kinase with ATP analogue and Mn.  1jkk: 2.4A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MG.  1jkl: 1.6A X-RAY STRUCTURE OF BINARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE  1jks: 1.5A X-RAY STRUCTURE OF APO FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE  1jkt: TETRAGONAL CRYSTAL FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE  1p4f: DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT  1wvw: Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors  1wvx: Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors  1wvy: Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors