Olke C. Uhlenbeck
| O. C. Uhlenbeck | |
|---|---|
| Residence | United States |
| Citizenship | American |
| Fields |
Biochemistry Biophysics |
| Institutions |
University of Illinois University of Colorado Northwestern University |
| Alma mater |
University of Michigan Harvard University |
| Doctoral advisor | Paul Doty |
| Known for | RNA synthesis from synthetic templates, RNA-protein interactions, RNA Biochemistry |
| Notes | |
|
His father was the famous Physicist George Eugene Uhlenbeck. | |
Olke C. Uhlenbeck is a biochemist presently at Northwestern University.[1] He was elected to the United States National Academy of Sciences in 1993 [2] and has published over 200 peer-reviewed articles.[3] His research group has led to many breakthroughs in RNA biochemistry, most notably the enzymatic synthesis of RNAs from synthetic DNA templates using T7 RNA polymerase.[4] Olke was a founding member of the RNA society.[5]
Early Contributions
As a graduate student in Paul Doty's lab, Olke showed that the anticodon of tRNA was accessible to hybridization to oligonucleotides.[6] Later, as a Miller Research Fellow in Ignacio Tinoco, Jr.'s lab he helped define an original model for RNA secondary structure prediction.[7]
Contributions from the Uhlenbeck Lab
Olke is a longstanding contributor to RNA biochemistry. His group has shown many important findings as well as developed important tools for RNA biochemists. Notable contributions include:
- Walker, G. C.; Uhlenbeck, OC; Bedows, E; Gumport, RI (1975). "T4-Induced RNA Ligase Joins Single-Stranded Oligoribonucleotides". Proceedings of the National Academy of Sciences. 72 (1): 122–6. Bibcode:1975PNAS...72..122W. doi:10.1073/pnas.72.1.122. PMC 432253
. PMID 1090929. - England, Thomas E.; Uhlenbeck, Olke C. (1978). "3′-Terminal labelling of RNA with T4 RNA ligase". Nature. 275 (5680): 560–1. Bibcode:1978Natur.275..560E. doi:10.1038/275560a0. PMID 692735.
- Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
- Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
- Hertel, Klemens J.; Herschlag, Daniel; Uhlenbeck, Olke C. (1994). "A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction". Biochemistry. 33 (11): 3374–85. doi:10.1021/bi00177a031. PMID 8136375.
- Johansson, H. E. (1998). "A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein". Proceedings of the National Academy of Sciences. 95: 9244–9. Bibcode:1998PNAS...95.9244J. doi:10.1073/pnas.95.16.9244.
- Sampson, J. R. (1988). "Biochemical and Physical Characterization of an Unmodified Yeast Phenylalanine Transfer RNA Transcribed in vitro". Proceedings of the National Academy of Sciences. 85: 1033–7. Bibcode:1988PNAS...85.1033S. doi:10.1073/pnas.85.4.1033. JSTOR 30928.
- Sampson, JR; Direnzo, A.; Behlen, L.; Uhlenbeck, O. (1989). "Nucleotides in yeast tRNAPhe required for the specific recognition by its cognate synthetase". Science. 243 (4896): 1363–6. Bibcode:1989Sci...243.1363S. doi:10.1126/science.2646717. PMID 2646717.
- Lariviere, F. J.; Wolfson, AD; Uhlenbeck, OC (2001). "Uniform Binding of Aminoacyl-tRNAs to Elongation Factor Tu by Thermodynamic Compensation". Science. 294 (5540): 165–8. Bibcode:2001Sci...294..165L. doi:10.1126/science.1064242. PMID 11588263.
See also
References
- ↑ "Northwestern University Department of Molecular Biosciences The Uhlenbeck Lab Home". Biochem.northwestern.edu. Retrieved 2011-03-02.
- ↑ "National Academy of Sciences:". Nasonline.org. Retrieved 2011-03-02.
- ↑ ""Uhlenbeck OC"[Author] - PubMed - NCBI". Ncbi.nlm.nih.gov. 2011-10-03. Retrieved 2011-12-02.
- ↑ Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
- ↑ "An Imperfect Account of the Founding of the RNA Society". The RNA society.
- ↑ Uhlenbeck, Olke C.; Baller, Julie; Doty, Paul (1970). "Complementary Oligonucleotide Binding to the Anticodon Loop of fMet-transfer RNA". Nature. 225 (5232): 508–10. Bibcode:1970Natur.225..508U. doi:10.1038/225508a0. PMID 5411856.
- ↑ Tinoco, Ignacio; Uhlenbeck, Olke C.; Levine, Mark D. (1971). "Estimation of Secondary Structure in Ribonucleic Acids". Nature. 230 (5293): 362–7. Bibcode:1971Natur.230..362T. doi:10.1038/230362a0. PMID 4927725.
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