List of number-one R&B singles of 1966 (U.S.)
These are the Billboard magazine R&B singles chart number one hits of 1966:
See also: 1966 in music, List of number-one R&B hits (United States)
| Issue Date | Song | Artist |
| January 1 | "I Got You (I Feel Good)" | James Brown |
| January 8 | "A Sweet Woman Like You" | Joe Tex |
| January 15 | "I Got You (I Feel Good)" | James Brown |
| January 22 | "Uptight (Everything's Alright)" | Stevie Wonder |
| January 29 | "Uptight (Everything's Alright)" | Stevie Wonder |
| February 5 | "Uptight (Everything's Alright)" | Stevie Wonder |
| February 12 | "Uptight (Everything's Alright)" | Stevie Wonder |
| February 19 | "Uptight (Everything's Alright)" | Stevie Wonder |
| February 26 | "Baby Scratch My Back" | Slim Harpo |
| March 5 | "Baby Scratch My Back" | Slim Harpo |
| March 12 | "634-5789 (Soulsville, U.S.A.)" | Wilson Pickett |
| March 19 | "634-5789 (Soulsville U.S.A.)" | Wilson Pickett |
| March 26 | "634-5789 (Soulsville U.S.A.)" | Wilson Pickett |
| April 2 | "634-5789 (Soulsville U.S.A.)" | Wilson Pickett |
| April 9 | "634-5789 (Soulsville U.S.A.)" | Wilson Pickett |
| April 16 | "634-5789 (Soulsville U.S.A.)" | Wilson Pickett |
| April 23 | "634-5789 (Soulsville U.S.A.)" | Wilson Pickett |
| April 30 | "Get Ready" | The Temptations |
| May 7 | "When a Man Loves a Woman" | Percy Sledge |
| May 14 | "When a Man Loves a Woman" | Percy Sledge |
| May 21 | "When a Man Loves a Woman" | Percy Sledge |
| May 28 | "When a Man Loves a Woman" | Percy Sledge |
| June 4 | "It's a Man's Man's Man's World" | James Brown |
| June 11 | "It's a Man's Man's Man's World" | James Brown |
| June 18 | "Hold On! I'm a Comin'" | Sam & Dave |
| June 25 | "Ain't Too Proud to Beg" | The Temptations |
| July 2 | "Ain't Too Proud to Beg" | The Temptations |
| July 9 | "Ain't Too Proud to Beg" | The Temptations |
| July 16 | "Ain't Too Proud to Beg" | The Temptations |
| July 23 | "Let's Go Get Stoned" | Ray Charles |
| July 30 | "Ain't Too Proud to Beg" | The Temptations |
| August 6 | "Ain't Too Proud to Beg" | The Temptations |
| August 13 | "Ain't Too Proud to Beg" | The Temptations |
| August 20 | "Ain't Too Proud to Beg" | The Temptations |
| August 27 | Blowin' in the Wind | Stevie Wonder |
| September 3 | "You Can't Hurry Love" | The Supremes |
| September 10 | "You Can't Hurry Love" | The Supremes |
| September 17 | "Land of a Thousand Dances" | Wilson Pickett |
| September 24 | "Beauty Is Only Skin Deep" | The Temptations |
| October 1 | "Beauty Is Only Skin Deep" | The Temptations |
| October 8 | "Beauty Is Only Skin Deep" | The Temptations |
| October 15 | "Beauty Is Only Skin Deep" | The Temptations |
| October 22 | "Beauty Is Only Skin Deep" | The Temptations |
| October 29 | "Reach Out I'll Be There" | The Four Tops |
| November 5 | "Reach Out I'll Be There" | The Four Tops |
| November 12 | "Love Is a Hurtin' Thing" | Lou Rawls |
| November 19 | "Knock On Wood" | Eddie Floyd |
| November 26 | "You Keep Me Hangin' On" | The Supremes |
| December 3 | "You Keep Me Hangin' On" | The Supremes |
| December 10 | "You Keep Me Hangin' On" | The Supremes |
| December 17 | "You Keep Me Hangin' On" | The Supremes |
| December 24 | "(I Know) I'm Losing You" | The Temptations |
| December 31 | "(I Know) I'm Losing You" | The Temptations |
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