Mavromichalis was born in Athens in 1850 into the renowned Mavromichalis family of Mani, which had fought during the Greek War of Independence. He was first elected to the Hellenic Parliament in 1879 and served as: Interior Minister (1895–1897, 1902–1903 and 1905) and Minister for Military Affairs (1904–1905), before becoming Prime Minister of Greece following the Goudi Revolt by the Military League and the fall of the Dimitrios Rallis government in 1909.
Under pressure from the League, Mavromichalis passed a large amount of ground-breaking legislation that the League demanded, including organization of the army, the justice and educational systems, and governmental organization.
Mavromichalis resigned as Prime Minister in January 1910, after a disagreement with the Military League. He died in Athens in 1916 and was buried with full honours.
He was a great-uncle of Princess Aspasia of Greece.
|Prime Minister of Greece
August 28, 1909 - January 31, 1910
| Succeeded by|
- Note: Greece officially adopted the Gregorian calendar on 16 February 1923 (which became 1 March). All dates prior to that, unless specifically denoted, are Old Style.