William Wickham may refer to:
- In the UK
- William Wickham (bishop) (1539–1595), English bishop
- William Wickham (1761–1840), British civil servant and politician; spymaster during the French Revolution.
- William Wickham (1831–1897), Member of Parliament for Petersfield, 1892–1897; grandson of William Wickham (1761–1840).
- William Wickham (1782-1860) social reformer and campaigner for the Parliamentary Reform Act 1832
- In the US
- William H. Wickham (1832–1893), New York mayor
- Williams Carter Wickham (1820–1888), American lawyer, judge, politician, and Confederate cavalry general