Born in Pforzheim, he lived most of his life in the Grand Duchy of Lithuania and at the court of Polish kings. In early 16th century he was made a high-ranking official at the Kraków mint. Soon after, in the year 1504 he moved to Kaunas, where he became prominent and influential citizen. Later Hosius relocated to Vilnius where he headed the newly opened Lithuanian Mint and took the offices of mayor (Castellan) of Vilnius between 1524 and 1535 and Flag-bearer of Vilnius Castle during the years 1528-1535.
From 1513, Hosius was appointed as a supervisor at the reconstructions of the Lower castle of Vilnius by King Sigismund I the Old and as a supervisor of the reconstruction of the Royal palace. From 1515 Hosius supervised the building of mills in the Grand Duchy. He is remembered as the builder of the Green Bridge (1532-1534), one of the first permanent bridges across the Neris River and the first recorded owner of the village of Bezdonys (since 1516). Hosius started the construction of St. Theresa Church in Vilnius. Simultaneously Ulrich Hosius started the construction works on The Holy Trinity asylum, that were finished by his son, Stanislaus Hosius in 1570, who rose to the ranks of a Catholic bishop, cardinal and a Papal legate. It was also Ulrich Hosius, who supervised the constructions of the first water-supply system of Vilnius.
- Ulrichas Hozijus. Visuotinė lietuvių enciklopedija, T. VII (Gorkai-Imermanas). – Vilnius: Mokslo ir enciklopedijų leidybos institutas, 2005. 662 p.
- M. Gumowski (1926). "Ulryk Hozjusz, ojciec kardynała, horodniczy wileński". Przegląd powszechny (in Polish). 171.
- Mirosław Gajewski. "Z historii Bezdan". Nasza Gazeta (in Polish). 10 (446).