UHRF2

UHRF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WY8, 1Z6U, 2E6S, 3OLN, 4PW5, 4PW6, 4PW7, 4TVR
Identifiers
Aliases	UHRF2, NIRF, RNF107, URF2, TDRD23, ubiquitin like with PHD and ring finger domains 2
External IDs	MGI: 1923718 HomoloGene: 17001 GeneCards: UHRF2
Gene ontology Molecular function • DNA binding • histone binding • zinc ion binding • ligase activity • protein binding • metal ion binding • ubiquitin protein ligase activity • ubiquitin-protein transferase activity Cellular component • nuclear heterochromatin • nucleus • nucleoplasm Biological process • protein autoubiquitination • positive regulation of cell cycle arrest • regulation of methylation-dependent chromatin silencing • cell cycle • cell differentiation • cell proliferation • maintenance of DNA methylation • protein ubiquitination • regulation of cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	115426	109113
Ensembl	ENSG00000147854	ENSMUSG00000024817
UniProt	Q96PU4	Q7TMI3
RefSeq (mRNA)	NM_152896	NM_144873
RefSeq (protein)	NP_690856.1	NP_659122.2
Location (UCSC)	Chr 9: 6.41 – 6.51 Mb	Chr 19: 30.03 – 30.09 Mb
PubMed search	[1]	[2]
Wikidata

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.^[3][4]

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.^[4]

References

Further reading

PDB gallery
1wy8: Solution Structure of the N-terminal Ubiquitin-like Domain in Human Np95/ICBP90-like Ring Finger Protein (NIRF)  1z6u: Np95-like ring finger protein isoform b [Homo sapiens]