TXNL4B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1XBS, 3GIX, 4IN0

Identifiers

Aliases

TXNL4B, DLP, Dim2, thioredoxin like 4B

External IDs

MGI: 2443724 HomoloGene: 9880 GeneCards: TXNL4B

Gene ontology
Molecular function	• protein binding
Cellular component	• U5 snRNP • U4/U6 x U5 tri-snRNP complex • spliceosomal complex • nucleus
Biological process	• mRNA splicing, via spliceosome • cell cycle • mRNA processing • spliceosomal complex assembly • RNA splicing
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


54957


234723

Ensembl


ENSG00000140830


ENSMUSG00000031723

UniProt


Q9NX01


Q8BUH1

RefSeq (mRNA)


NM_017853 NM_001142317 NM_001142318 NM_001324354 NM_001324355


NM_175646

RefSeq (protein)


NP_001135789.1 NP_001135790.1 NP_060323.1


NP_783577.2

Location (UCSC)

Chr 16: 72.04 – 72.09 Mb

Chr 8: 109.57 – 109.57 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Thioredoxin-like protein 4B is a protein that in humans is encoded by the TXNL4B gene.^[3]^[4]

Interactions

TXNL4B has been shown to interact with PRPF6.^[3]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Sun X, Zhang H, Wang D, Ma D, Shen Y, Shang Y (Jul 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J Biol Chem. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. PMID 15161931.
↑ "Entrez Gene: TXNL4B thioredoxin-like 4B".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (2001). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily" (PDF). Physiol. Genomics. 1 (3): 109–18. PMID 11015569.
Schelling P, Claus MT, Johner R, Marquez VE, Schulz GE, Scapozza L (2004). "Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells". J. Biol. Chem. 279 (31): 32832–8. doi:10.1074/jbc.M313343200. PMID 15163659.
Simeoni F, Arvai A, Bello P, Gondeau C, Hopfner KP, Neyroz P, Heitz F, Tainer J, Divita G (2005). "Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2". Biochemistry. 44 (36): 11997–2008. doi:10.1021/bi050427o. PMID 16142897.
Jin T, Howard AJ, Golemis EA, Wang Y, Zhang YZ (2006). "Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 3): 282–4. doi:10.1107/S1744309105002861. PMC 1952293. PMID 16511018.

PDB gallery

1xbs: Crystal structure of human dim2: a dim1-like protein

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TXNL4B

Interactions

References

Further reading