TNFAIP3

TNFAIP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EQF, 2EQG, 2VFJ, 3DKB, 3OJ3, 3OJ4, 3VUW, 3VUX, 3VUY, 3ZJD, 3ZJE, 3ZJF, 3ZJG, 4ZRH, 4ZS5
Identifiers
Aliases	TNFAIP3, A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3
External IDs	MGI: 1196377 HomoloGene: 4582 GeneCards: TNFAIP3
Genetically Related Diseases
systemic lupus erythematosus, psoriasis[1]
Gene ontology Molecular function • DNA binding • cysteine-type peptidase activity • thiol-dependent ubiquitinyl hydrolase activity • zinc ion binding • metal ion binding • ubiquitin-protein transferase activity • protease binding • protein self-association • peptidase activity • ligase activity • kinase binding • K63-linked polyubiquitin binding • ubiquitin binding • protein binding • catalytic activity • thiol-dependent ubiquitin-specific protease activity • hydrolase activity Cellular component • cytoplasm • cytosol • lysosome • extracellular exosome • nucleus Biological process • regulation of germinal center formation • positive regulation of hepatocyte proliferation • negative regulation of endothelial cell apoptotic process • negative regulation of interleukin-1 beta production • negative regulation of smooth muscle cell proliferation • regulation of vascular wound healing • B-1 B cell homeostasis • protein K48-linked deubiquitination • positive regulation of protein catabolic process • negative regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of defense response to virus by host • protein deubiquitination involved in ubiquitin-dependent protein catabolic process • positive regulation of cellular protein catabolic process • negative regulation of toll-like receptor 2 signaling pathway • negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway • regulation of tumor necrosis factor-mediated signaling pathway • negative regulation of interleukin-6 production • negative regulation of B cell activation • negative regulation of toll-like receptor 5 signaling pathway • tolerance induction to lipopolysaccharide • response to muramyl dipeptide • negative regulation of chronic inflammatory response • negative regulation of cell death • negative regulation of I-kappaB kinase/NF-kappaB signaling • proteolysis • establishment of protein localization to vacuole • protein deubiquitination • negative regulation of protein ubiquitination • protein K48-linked ubiquitination • protein K63-linked deubiquitination • negative regulation of CD40 signaling pathway • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • protein oligomerization • protein K11-linked deubiquitination • regulation of inflammatory response • negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway • negative regulation of innate immune response • negative regulation of osteoclast proliferation • negative regulation of tumor necrosis factor production • negative regulation of type I interferon production • metabolic process • inflammatory response • response to molecule of bacterial origin • negative regulation of NF-kappaB transcription factor activity • negative regulation of interleukin-2 production • negative regulation of inflammatory response • negative regulation of toll-like receptor 3 signaling pathway • nucleotide-binding oligomerization domain containing signaling pathway • cellular response to lipopolysaccharide • negative regulation of toll-like receptor 4 signaling pathway • negative regulation of bone resorption • cellular response to hydrogen peroxide • apoptotic process • protein ubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7128	21929
Ensembl	ENSG00000118503	ENSMUSG00000019850
UniProt	P21580	Q60769
RefSeq (mRNA)	NM_001270507 NM_001270508 NM_006290	NM_001166402 NM_009397
RefSeq (protein)	NP_001257436.1 NP_001257437.1 NP_006281.1	NP_033423.3
Location (UCSC)	Chr 6: 137.87 – 137.88 Mb	Chr 10: 19 – 19.02 Mb
PubMed search	[2]	[3]
Wikidata

Tumor necrosis factor, alpha-induced protein 3 is a protein that in humans is encoded by the TNFAIP3 gene.^[4][5]

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.^[5]

Interactions

TNFAIP3 has been shown to interact with TNIP1,^[6] TRAF1,^[7][8] TRAF2,^[7] IKBKG,^[9] TAX1BP1,^[10] YWHAB,^[11] YWHAZ,^[11][12] TRAF6^[8][13] and YWHAH.^[11][12]

Association with rheumatoid arthritis

The TNFAIP3 locus is implicated as a positively associated factor in rheumatoid arthritis (RA). The rs5029937 (T) and the rs6920220 (A) SNPs increase risk of RA by 20 to 40% respectively.^[14] A third SNP, rs10499194 (T) is found less often in rheumatoid arthritis but this negative association may not be statistically meaningful.

References

Further reading