Small nucleolar RNA U2-19

Small nucleolar RNA U2-19
Predicted secondary structure and sequence conservation of snoU2_19
Identifiers
Symbol	snoU2_19
Rfam	RF00494
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	0006396 0005730
SO	0000593

Small nucleolar RNA U2-19 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA U2-19 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^[1] snoRNA U2-19 directs 2'-O-methylation of U2 spliceosomal RNA G-19.^[2]

References

External links

• Page for Small nucleolar RNA U2-19 at Rfam