Slippery sequence
A slippery sequence is a small section of codon nucleotide sequences (usually UUUAAAC) that controls the rate of ribosomal frameshifting. A slippery sequence causes a faster ribosomal transfer which in turn can cause the reading ribosome to "slip." This allows a tRNA to shift by 1 base after it has paired with its anticodon, changing the reading frame.[1][2][3][4][5]
See also
- Nucleic acid tertiary structure
- Open reading frame
- Ribosomal frameshifting
- Translational frameshift
- Transposable element
References
- ↑ Green L, Kim CH, Bustamante C, Tinoco I Jr. "Characterization of the Mechanical Unfolding of RNA Pseudoknots." J Mol Biol. 26 May 2007
- ↑ Chien-Hung Yu, Mathieu H. M. Noteborn and René C. L. Olsthoorn.Stimulation of ribosomal frameshifting by antisense LNA. Nucl.Acids Res (2010) 38 (22):8277-8238
- ↑ http://www.path.cam.ac.uk/research/investigators/brierley/research.html
- ↑ "Molecular Biology: Frameshifting occurs at slippery sequences". Molecularstudy.blogspot.com. Retrieved 2013-07-28.
- ↑ Farabaugh, P. J.; Björk, G. R. (15 March 1999). "How translational accuracy influences reading frame maintenance". EMBO J. 18 (6): 1427–1434. doi:10.1093/emboj/18.6.1427. PMC 1171232
. PMID 10075915 – via PubMed.
External links
- Pseudobase
- Recode
- Frameshifting, Ribosomal at the US National Library of Medicine Medical Subject Headings (MeSH)
- Wise2 - aligns a protein against a DNA sequence allowing frameshifts and introns
- FastY - compare a DNA sequence to a protein sequence database, allowing gaps and frameshifts
- Path - tool that compares two frameshift proteins (back-translation principle)
- Recode2 - Database of recoded genes, including those that require programmed Translational frameshift.
- Page for Coronavirus frameshifting stimulation element at Rfam
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