Scaffolding (bioinformatics)

This is an example of a scaffold.

Scaffolding is a technique used in bioinformatics. It is defined as follows:[1]

Link together a non-contiguous series of genomic sequences into a scaffold, consisting of sequences separated by gaps of known length. The sequences that are linked are typically contiguous sequences corresponding to read overlaps.

The scaffold can be created using either optical mapping or mate-pair sequencing.[2]

See also

contig

  1. ↑ "EDAM Ontology of Bioinformatics Operations and Data Formats".
  2. ↑ Flot, Jean-François; Marie-Nelly, Hervé; Koszul, Romain (2015-10-07). "Contact genomics: scaffolding and phasing (meta)genomes using chromosome 3D physical signatures". FEBS letters. 589 (20 Pt A): 2966–2974. doi:10.1016/j.febslet.2015.04.034. ISSN 1873-3468. PMID 25935414.


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