ST3GAL4

Identifiers

ST3GAL4, CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ, ST3 beta-galactoside alpha-2,3-sialyltransferase 4

External IDs

MGI: 1316743 HomoloGene: 4572 GeneCards: ST3GAL4

Gene ontology
Molecular function	• transferase activity • beta-galactoside (CMP) alpha-2,3-sialyltransferase activity • transferase activity, transferring glycosyl groups • sialyltransferase activity • monosialoganglioside sialyltransferase activity
Cellular component	• integral component of membrane • integral component of Golgi membrane • Golgi apparatus • Golgi membrane • Golgi cisterna membrane • extracellular region • extracellular exosome • membrane
Biological process	• sialylation • cognition • ganglioside biosynthetic process • protein glycosylation • O-glycan processing • keratan sulfate biosynthetic process • oligosaccharide metabolic process • protein N-linked glycosylation via asparagine
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6484


20443

Ensembl


ENSG00000110080


ENSMUSG00000032038

UniProt


Q11206


Q91Y74

RefSeq (mRNA)


NM_001254757 NM_001254758 NM_001254759 NM_006278


NM_009178

RefSeq (protein)


NP_001241686.1 NP_001241687.1 NP_001241688.1 NP_006269.1


NP_033204.2

Location (UCSC)

Chr 11: 126.36 – 126.44 Mb

Chr 9: 35.05 – 35.12 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Kitagawa H, Mattei MG, Paulson JC (Feb 1996). "Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase". J Biol Chem. 271 (2): 931–8. doi:10.1074/jbc.271.2.931. PMID 8557707.
↑ Kitagawa H, Paulson JC (Feb 1994). "Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups". J Biol Chem. 269 (2): 1394–401. PMID 8288606.
↑ "Entrez Gene: ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4".

Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. doi:10.1073/pnas.86.9.3384. PMC 287137. PMID 2541446.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–6. PMC 250699. PMID 2542563.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
Munro S (1995). "An investigation of the role of transmembrane domains in Golgi protein retention". EMBO J. 14 (19): 4695–704. PMC 394566. PMID 7588599.
Chang ML, Eddy RL, Shows TB, Lau JT (1995). "Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies". Glycobiology. 5 (3): 319–25. doi:10.1093/glycob/5.3.319. PMID 7655169.
Sasaki K, Watanabe E, Kawashima K, et al. (1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection". J. Biol. Chem. 268 (30): 22782–7. PMID 7901202.
Basu SS, Basu M, Li Z, Basu S (1996). "Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line". Biochemistry. 35 (16): 5166–74. doi:10.1021/bi960239l. PMID 8611500.
Saito S, Yamashita S, Endoh M, et al. (2003). "Clinical significance of ST3Gal IV expression in human renal cell carcinoma". Oncol. Rep. 9 (6): 1251–5. doi:10.3892/or.9.6.1251. PMID 12375029.
Grahn A, Larson G (2003). "Identification of nine alternatively spliced alpha2,3-sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues". Glycoconj. J. 18 (10): 759–67. doi:10.1023/A:1021199300718. PMID 12441665.
Moody AM, North SJ, Reinhold B, et al. (2003). "Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction". J. Biol. Chem. 278 (9): 7240–6. doi:10.1074/jbc.M210468200. PMID 12459555.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Taniguchi A, Hioki M, Matsumoto K (2003). "Transcriptional regulation of human Galbeta1,3GalNAc/Galbeta1, 4GlcNAc alpha2,3-sialyltransferase (hST3Gal IV) gene in testis and ovary cell lines". Biochem. Biophys. Res. Commun. 301 (3): 764–8. doi:10.1016/S0006-291X(03)00041-X. PMID 12565846.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Higai K, Miyazaki N, Azuma Y, Matsumoto K (2007). "Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene". FEBS Lett. 580 (26): 6069–75. doi:10.1016/j.febslet.2006.09.073. PMID 17054948.
Szabo R, Skropeta D, et al. (2016). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities.". Med. Res. Rev. 36: ahead of print. doi:10.1002/med.21407.

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ST3GAL4

References

Further reading