He was born at Wickford in Essex, where his family are said to have been Lords of the Manor of Wickford. He was a fellow of Merton College, Oxford, became a clerk of the Chancery, and was appointed Archdeacon of Winchester in 1368.
He seems to have been a man of considerable diplomatic and military ability, and was entrusted by King Edward III with a number of missions to the rulers of Flanders and Brabant and the King of Aragon. In 1373 he was made Constable of Bordeaux and later joined with the Seneschal in the government of Aquitaine.
O'Flanagan records that in 1375 the royal judges in Aquitaine, in a lawsuit in which Wikeford was the defendant, gave judgement against him without hearing him in his own defence and imposed financial penalties of great severity on him. Wikeford appealed to the King in Council, and the King immediately ordered the judgement to be cancelled. The episode suggests that Wikeford, though clearly a valued Crown servant, was not generally popular.
In 1375 Wickford became Archbishop of Dublin and a year later he was made Lord Chancellor. O'Flanagan believes (despite the lack of written records for this period) that he was a gifted and conscientious Chancellor; in addition to his judicial business he undertook a vast range of official duties, including the holding of a Parliament at Castledermot. He was granted the manor of Swords, near Dublin, and the right to hold a fair there. He ceased to be Chancellor about 1380, and as he aged his duties as Primate became increasingly onerous. In 1390 he was permitted to return to England in the hope of improving his health, but he died in England on 29 August.
O'Flanagan praises him as a wise and learned judge and a man of great ability. However, the judgment given against him in his Aquitainian lawsuit suggests that he was not popular, and as Archbishop he showed the harsher side of his character by expelling all beggars from his diocese.