Repulsive guidance molecule

Repulsive Guidance Molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin). RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth.[1]

Family members

RGM domain family, member A
Identifiers
Symbol RGMA
Alt. symbols RGM
Entrez 56963
HUGO 30308
OMIM 607362
RefSeq NM_020211
UniProt Q96B86
Other data
Locus Chr. 15 q26.1
RGM domain family, member B
Identifiers
Symbol RGMB
Alt. symbols DRAGON
Entrez 285704
HUGO 26896
OMIM 612687
RefSeq NM_173670
UniProt Q6NW40
Other data
Locus Chr. 5 q21.1
hemochromatosis type 2
Identifiers
Symbol HFE2
Alt. symbols RGMC, HJV, hemojuvelin
Entrez 148738
HUGO 4887
OMIM 608374
RefSeq NM_145277
UniProt Q6ZVN8
Other data
Locus Chr. 1 q21.2

References

  1. ↑ Severyn CJ, Shinde U, Rotwein P (September 2009). "Molecular biology, genetics and biochemistry of the repulsive guidance molecule family". Biochem. J. 422 (3): 393–403. doi:10.1042/BJ20090978. PMID 19698085.
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