ROCK2

ROCK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2
External IDs MGI: 107926 HomoloGene: 21010 GeneCards: ROCK2
Targeted by Drug
fasudil, 4-[(1R)-1-aminoethyl]-N-pyridin-4-yl-1-cyclohexanecarboxamide[1]
Orthologs
Species Human Mouse
Entrez

9475

19878

Ensembl

ENSG00000134318

ENSMUSG00000020580

UniProt

O75116

P70336

RefSeq (mRNA)

NM_004850
NM_001321643

NM_009072

RefSeq (protein)

NP_004841.2
NP_001308572.1

NP_033098.2

Location (UCSC) Chr 2: 11.18 – 11.35 Mb Chr 12: 16.89 – 16.99 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. [4]

Function

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

References

  1. ↑ "Drugs that physically interact with Rho-associated protein kinase 2 view/edit references on wikidata".
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ "Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.

Further reading

  • Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry. 41 (28): 8948–53. doi:10.1021/bi0258243. PMID 12102637. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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