RIG-I

DDX58
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LWD, 2LWE, 2QFB, 2QFD, 2RMJ, 2YKG, 3LRN, 3LRR, 3NCU, 3OG8, 3ZD6, 3ZD7, 4AY2, 4BPB, 4NQK, 4ON9, 4P4H, 5E3H, 5F98, 5F9F, 5F9H
Identifiers
Aliases	DDX58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIGI, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58
External IDs	MGI: 2442858 HomoloGene: 32215 GeneCards: DDX58
Gene ontology Molecular function • nucleotide binding • helicase activity • zinc ion binding • metal ion binding • hydrolase activity, acting on acid anhydrides • protein binding • single-stranded RNA binding • identical protein binding • RNA binding • double-stranded RNA binding • double-stranded DNA binding • hydrolase activity • ATP binding • nucleic acid binding Cellular component • cytoplasm • cytosol • cell projection • membrane • bicellular tight junction • plasma membrane • ruffle membrane • cell junction • actin cytoskeleton • cytoskeleton Biological process • regulation of cell migration • response to exogenous dsRNA • positive regulation of interferon-alpha production • immune system process • response to virus • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of transcription factor import into nucleus • cytoplasmic pattern recognition receptor signaling pathway in response to virus • positive regulation of gene expression • positive regulation of granulocyte macrophage colony-stimulating factor production • defense response to virus • positive regulation of interleukin-8 production • positive regulation of interleukin-6 production • negative regulation of type I interferon production • detection of virus • viral process • innate immune response • positive regulation of transcription from RNA polymerase II promoter • RIG-I signaling pathway • regulation of type III interferon production • positive regulation of defense response to virus by host • positive regulation of interferon-beta production Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23586	230073
Ensembl	ENSG00000107201	ENSMUSG00000040296
UniProt	O95786	Q6Q899
RefSeq (mRNA)	NM_014314	NM_172689
RefSeq (protein)	NP_055129.2	NP_766277.3
Location (UCSC)	Chr 9: 32.46 – 32.53 Mb	Chr 4: 40.2 – 40.24 Mb
PubMed search	[1]	[2]
Wikidata

RIG-I (retinoic acid-inducible gene I) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded (in humans) by the DDX58 gene. RIG-I is part of the RIG-I-like receptor family, which also includes MDA5 and LGP2, and functions as a pattern recognition receptor that is a sensor for viruses such as influenza A, Sendai virus, and flavivirus. Certain retroviruses, such as HIV-1, encode a protease that directs RIG-1 to the lysosome for degradation, and thereby evade RIG-1 mediated signaling.^[3] RIG-I typically recognizes short (< 4000nt) 5′ triphosphate uncapped double stranded or single stranded RNA.^[4][5][6] RIG-I and MDA5 are involved in activating MAVS and triggering an antiviral response.^[7] RIG-I is also able to detect non-self 5′-triphosphorylated dsRNA transcribed from AT-rich dsDNA by DNA-dependent RNA polymerase III (Pol III). For many viruses, effective RIG-I-mediated antiviral responses are dependent on functionally active LGP2.^[8]

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. RIG-I contains a RNA helicase-DEAD box motifs and a caspase recruitment domain (CARD). RIG-I is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.^[9]

References

Further reading