RGS5
Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.[3][4]
The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[supplied by OMIM][4]
Interactions
RGS5 has been shown to interact with GNAO1,[5][6] GNAI2[5][6] and GNAI3.[5][6]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T (October 1998). "Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene". J Hum Genet. 43 (3): 202–5. doi:10.1007/s100380050071. PMID 9747037.
- 1 2 "Entrez Gene: RGS5 regulator of G-protein signalling 5".
- 1 2 3 Chen, C; Zheng B; Han J; Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. UNITED STATES. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700.
- 1 2 3 Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (February 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. England. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162.
Further reading
- Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.
- Cismowski MJ, Takesono A, Ma C, et al. (1999). "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling". Nat. Biotechnol. 17 (9): 878–83. doi:10.1038/12867. PMID 10471929.
- Adams LD, Geary RL, McManus B, Schwartz SM (2000). "A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media". Circ. Res. 87 (7): 623–31. doi:10.1161/01.res.87.7.623. PMID 11009569.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948
. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Zhou J, Moroi K, Nishiyama M, et al. (2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. PMID 11253162.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Morris DW, Rodgers A, McGhee KA, et al. (2005). "Confirming RGS4 as a susceptibility gene for schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 125 (1): 50–3. doi:10.1002/ajmg.b.20109. PMID 14755443.
- Berger M, Bergers G, Arnold B, et al. (2005). "Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization". Blood. 105 (3): 1094–101. doi:10.1182/blood-2004-06-2315. PMID 15459006.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Liang Y, Li C, Guzman VM, et al. (2005). "Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues". FEBS J. 272 (3): 791–9. doi:10.1111/j.1742-4658.2004.04516.x. PMID 15670159.
- Adams LD, Geary RL, Li J, et al. (2006). "Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap". Arterioscler. Thromb. Vasc. Biol. 26 (2): 319–25. doi:10.1161/01.ATV.0000196647.45718.d6. PMID 16293795.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Rhee KH, Nam KH, Lee WH, et al. (2007). "Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-". Protein Pept. Lett. 13 (9): 945–9. doi:10.2174/092986606778256225. PMID 17100651.
- Bodenstein J, Sunahara RK, Neubig RR (2007). "N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells". Mol. Pharmacol. 71 (4): 1040–50. doi:10.1124/mol.106.029397. PMID 17220356.
- Yang Z, Gaudio S, Song W, et al. (2007). "Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5)". Cell. Physiol. Biochem. 20 (5): 303–10. doi:10.1159/000107516. PMID 17762159.
PDB gallery |
|---|
|
| 2crp: Solution structure of the RGS domain of regulator of G-protein signalling 5 (RGS 5) |
|
|
