RFC4

RFC4
Identifiers
Aliases	RFC4, A1, RFC37, replication factor C subunit 4
External IDs	MGI: 2146571 HomoloGene: 6288 GeneCards: RFC4
Gene ontology Molecular function • nucleotide binding • DNA binding • single-stranded DNA-dependent ATPase activity • protein binding • enzyme binding • ATP binding • DNA clamp loader activity Cellular component • DNA replication factor C complex • Ctf18 RFC-like complex • nucleoplasm • nucleus Biological process • nucleotide-excision repair, DNA gap filling • error-free translesion synthesis • DNA strand elongation involved in DNA replication • error-prone translesion synthesis • DNA replication • telomere maintenance via recombination • positive regulation of DNA-directed DNA polymerase activity • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • DNA damage response, detection of DNA damage • regulation of signal transduction by p53 class mediator • nucleotide-excision repair, DNA incision, 5'-to lesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5984	106344
Ensembl	ENSG00000163918	ENSMUSG00000022881
UniProt	P35249	Q99J62
RefSeq (mRNA)	NM_181573 NM_002916	NM_145480
RefSeq (protein)	NP_002907.1 NP_853551.1	NP_663455.1
Location (UCSC)	Chr 3: 186.79 – 186.81 Mb	Chr 16: 23.11 – 23.13 Mb
PubMed search	[1]	[2]
Wikidata

Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.^[3][4]

Function

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.^[4]

Interactions

RFC4 has been shown to interact with:

• BRD4,^[5]
• CHTF18,^[6]
• PCNA,^[7][8]
• RFC2,^[7][9]
• RFC3,^[10][11] and
• RFC5.^{[7][9][10][12]}

References

Further reading