Procollagen peptidase

procollagen (type III) N-endopeptidase
Symbol PCOLN3
Alt. symbols PRSM1
Entrez 5119
HUGO 8740
OMIM 164010
RefSeq NM_002768
UniProt Q9HD42
Other data
EC number
Locus Chr. 16 q24.3

Procollagen peptidase (EC, procollagen N-terminal peptidase, procollagen aminopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, procollagen aminoterminal protease, procollagen N-terminal proteinase, type I/II procollagen N-proteinase, type III procollagen) is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome.[1]

The enzyme is present in the skin of rats and humans.[2]


  2. Lapière, C. M.; Lenaers, A.; Kohn, L. D. (1971). "Procollagen Peptidase: An Enzyme Excising the Coordination Peptides of Procollagen". Proceedings of the National Academy of Sciences of the United States of America. 68 (12): 3054–3058. doi:10.1073/pnas.68.12.3054. PMC 389589Freely accessible. PMID 5289249.
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