Podostroma cornu-damae

Podostroma cornu-damae
Scientific classification
Kingdom: Fungi
Division: Ascomycota
Class: Sordariomycetes
Order: Hypocreales
Family: Hypocreaceae
Genus: Podostroma
Species: P. cornu-damae
Binomial name
Podostroma cornu-damae
(Patouillard) Hongo & Izawa
Synonyms[1]
  • Hypocrea cornu-damae Pat.
  • Podocrea cornu-damae (Pat.) Sacc. & D.Sacc.
Podostroma cornu-damae
View the Mycomorphbox template that generates the following list

Mycological characteristics

smooth hymenium
no distinct cap
hymenium attachment is irregular or not applicable
lacks a stipe

spore print is yellow

to brown
ecology is saprotrophic
edibility: deadly

Podostroma cornu-damae (Japanese: カエンタケ) is a species of fungus in the family Hypocreaceae. The fruit bodies of the fungus are highly toxic, and have been responsible for several fatalities in Japan. The fungus contains several trichothecene mycotoxins.

Taxonomy

The species was originally described as Hypocrea cornu-damae by Narcisse Théophile Patouillard in 1895,[2] and later transferred to the genus Podocrea in 1905 by Pier Andrea Saccardo.[3] In 1994 Japanese mycologists Tsuguo Hongo and Masana Izawa placed the species in the genus Podostroma.[1]

Description

The conidiophores (specialized fungal hyphae that produce conidia) are up to 400 μm high and about 2–4 μm wide in the main axial hyphae. The phialides are arranged in tufts with narrow angles at the top, similar to the branching hyphae found in Trichoderma species. The conidia are roughly spherical with a truncate base in each spore, pale green in color, and measure 2.5–3.5 μm in diameter. Their surfaces are almost smooth, but sometimes appearing very faintly roughened with light microscopy.[4]

Toxicity

Several poisonings have been reported in Japan resulting from consumption of the fungus. In 1999, one of a group of five people from Niigata prefecture died two days after consuming about 1 gram (0.035 oz) of fruit body that had been soaked in sake. In 2000, an individual from Gunma prefecture died after eating the fried mushroom. Symptoms associated with consumption in these cases included stomach pains, changes in perception, decrease in the number of leukocytes and thrombocytes, peeling skin on the face, hair loss, and shrinking of the cerebellum, resulting in speech impediment and problems with voluntary movement.[5] In another instance, an autopsy revealed multiple organ failure, including acute kidney failure, liver necrosis and disseminated intravascular coagulation.[6] In one case of poisoning, the patient suffered from hemophagocytosis, in addition to severe leukocytopenia and thrombocytopenia seven days after ingesting the fungus. Plasmapheresis and administration of granulocyte colony-stimulating factor were used to treat the blood disorders. The authors suggested that these treatments, in addition to the large volume of administered intravenous fluid—9 liters (2.0 imp gal; 2.4 U.S. gal) over a 12-hour period—were responsible for his successful recovery.[7]

The poisoning symptoms are similar to those observed previously with animals that had consumed trichothecene mycotoxins. Japanese researchers detected the presence of the macrocyclic trichothecenes satratoxin H, satratoxin H 12′,13′-diacetate, satratoxin H 12′-acetate, and satratoxin H 13′-acetate. When grown in liquid culture the fungus additionally produces roridin E, verrucarin J, and satratoxin H. With the exception of verrucarin J, a 0.0005 grams (1.8×10−5 oz) dose of all of these compounds, when injected into the abdomen of mice, will result in their death the following day.[5]

See also

References

  1. 1 2 "Podostroma cornu-damae (Pat.) Hongo & Izawa 1994". MycoBank. International Mycological Association. Retrieved 2010-10-20.
  2. ↑ Patouillard NT. (1895). "Enumeration des champignons recoltes par les RR. PP. Farges at Soulie, dans le Thibet oriental at le Su-tchuen". Bulletin de la Société Mycologique de France (in French). 11: 196–99.
  3. ↑ Saccardo PA, Saccardo D (1905). "Supplementum universale. Pars VI. Hymenomycetae-Laboulbeniomycetae". Sylloge Fungorum (in French). 17: 799.
  4. ↑ "Revision of the Hypocreales with cultural observations. V. Podostroma giganteum Imai, P. cornu-damae (Pat.) Noedijn and Hypocrea pseudogelatinosa sp. nov". Reports of the Tottori Mycological Institute (Japan). 10: 421–27. 1973.
  5. 1 2 Saikawa Y, Okamoto H, Inui T, Makabe M, Okuno T, Suda T, Hashimoto K, Nakata M. "Toxic principles of a poisonous mushroom Podostroma cornu-damae". Tetrahedron. 57 (39): 8277–81. doi:10.1016/S0040-4020(01)00824-9.
  6. ↑ Koichi M, Haruo T, Toshihiro Y, Masami O, Sadao N, Koichiro K (2003). "Case report: food poisoning to death by Podostroma cornu-damae, its case history and autopsy findings". Acta Criminologiae et Medicinae Legalis Japonica (in Japanese). 69 (1): 14–20.
  7. ↑ Suzuki M, Katoh Y, Kumagai H, Saitoh M, Ishikawa H, Itoh H, Shimazu K (2002). "[Successful treatment in a case of Podostroma cornu-damae poisoning, a deadly poisonous mushroom]". Chudoku Kenkyu (in Japanese). 15 (2): 177–82. PMID 12108023.
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