Phytoene synthase
| 15-cis-phytoene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.32 | ||||||||
| CAS number | 50936-61-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Phytoene synthase (EC 2.5.1.32, prephytoene-diphosphate synthase, 15-cis-phytoene synthase, PSase, geranylgeranyl-diphosphate geranylgeranyltransferase) is a transferase enzyme involved in the biosynthesis of carotenoids. It catalyzes the conversion of geranylgeranyl pyrophosphate to phytoene.[1][2][3] This enzyme catalyses the following chemical reaction
- 2 geranylgeranyl diphosphate 15-cis-phytoene + 2 diphosphate (overall reaction)
- (1a) 2 geranylgeranyl diphosphate diphosphate + prephytoene diphosphate
- (1b) prephytoene diphosphate 15-cis-phytoene + diphosphate
This enzyme requires Mn2+ for activity. It belongs to squalene/phytoene synthase family of proteins.
References
- ↑ Phytoene synthase
- ↑ Gregonis, D.E.; Rilling, H.C. (1974). "The stereochemistry of trans-phytoene synthesis. Some observations on lycopersene as a carotene precursor and a mechanism for the synthesis of cis- and trans-phytoene". Biochemistry. 13 (7): 1538–1542. doi:10.1021/bi00704a033. PMID 4819767.
- ↑ Misawa, N.; Truesdale, M.R.; Sandmann, G.; Fraser, P.D.; Bird, C.; Schuch, W.; Bramley, P.M. (1994). "Expression of a tomato cDNA coding for phytoene synthase in Escherichia coli, phytoene formation in vivo and in vitro, and functional analysis of the various truncated gene products". J. Biochem. (Tokyo). 116 (5): 980–985. PMID 7896759.
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