Renal tissue kallikrein

Tissue kallikrein
Identifiers
EC number 3.4.21.35
CAS number 389069-73-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Tissue kallikrein (EC 3.4.21.35, glandular kallikrein, pancreatic kallikrein, submandibular kallikrein, submaxillary kallikrein, kidney kallikrein, urinary kallikrein, kallikrein, salivary kallikrein, kininogenin, kininogenase, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, depot-padutin, urokallikrein, dilminal D, onokrein P) is an enzyme.[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] This enzyme catalyses the following chemical reaction

Preferential cleavage of Arg- bonds in small molecule substrates. It acts highly selectively to release kallidin (lysyl-bradykinin) from kininogen

This enzyme is formed from tissue prokallikrein by activation with trypsin.

See also

References

  1. ↑ Fiedler, F.; Fink, E.; Tschesche, H.; Fritz, H. (1981). "Porcine glandular kallikreins". Methods Enzymol. 80: 493–532. doi:10.1016/s0076-6879(81)80042-0. PMID 7043199.
  2. ↑ Anundi, H.; Ronne, H.; Peterson, P.A.; Rask, L. (1982). "Partial amino-acid sequence of the epidermal growth-factor-binding protein". Eur. J. Biochem. 129: 365–371. doi:10.1111/j.1432-1033.1982.tb07059.x. PMID 6295764.
  3. ↑ Pesquero, J.L.; Boschcov, P.; Oliveira, M.C.F.; Paiva, A.C.M. (1982). "Effect of substrate size on tonin activity". Biochem. Biophys. Res. Commun. 108: 1441–1446. doi:10.1016/s0006-291x(82)80068-5. PMID 6295383.
  4. ↑ Gutkowska, J.; Corvol, P.; Figueiredo, A.F.S.; Inagami, T.; Bouhnik, J.; Genest, J. (1984). "Kinetic studies of rat renin and tonin on purified rat angiotensinogen". Can. J. Biochem. Cell Biol. 62: 136–142. PMID 6097352.
  5. ↑ Kato, H.; Enjyoji, K.; Miyata, T.; Hayashi, I.; Oh-Ishi, S.; Iwanaga, S. (1985). "Demonstration of arginyl-bradykinin moiety in rat HMW kininogen: direct evidence for liberation of bradykinin by rat glandular kallikreins". Biochem. Biophys. Res. Commun. 127: 289–295. doi:10.1016/s0006-291x(85)80157-1. PMID 3844939.
  6. ↑ Akiyama, K.; Nakamura, T.; Iwanaga, S.; Hara, M. (1987). "The chymotrypsin-like activity of human prostate-specific antigen, γ-seminoprotein". FEBS Lett. 225: 168–172. doi:10.1016/0014-5793(87)81151-1. PMID 3691800.
  7. ↑ Evans, B.A.; Drinkwater, C.C.; Richards, R.I. (1987). "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus". J. Biol. Chem. 262: 8027–8034. PMID 3036794.
  8. ↑ Fiedler, F. (1987). "Effects of secondary interactions on the kinetics of peptide and peptide ester hydrolysis by tissue kallikrein and trypsin". Eur. J. Biochem. 163: 303–312. doi:10.1111/j.1432-1033.1987.tb10801.x. PMID 3643848.
  9. ↑ Fujinaga, M.; James, M.N.G. (1987). "Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 Å resolution". J. Mol. Biol. 195: 373–396. doi:10.1016/0022-2836(87)90658-9. PMID 2821276.
  10. ↑ Kato, H.; Nakanishi, E.; Enjyoji, K.; Hayashi, I.; Oh-ishi, S.; Iwanaga, S. (1987). "Characterization of serine proteinases isolated from rat submaxillary gland: with special reference to the degradation of rat kininogens by these enzymes". J. Biochem. (Tokyo). 102: 1389–1404. PMID 3482210.
  11. ↑ Bailey, G.S. (1989). "Rat pancreas kallikrein". Methods Enzymol. 163: 115–128. doi:10.1016/0076-6879(88)63013-8. PMID 3237072.
  12. ↑ Blaber, M.; Isackson, P.J.; Marsters, J.C.; Jr.; Burnier, J.P.; Bradshaw, R.A. (1988). "Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland". Biochemistry. 28: 7813–7819. doi:10.1021/bi00445a043. PMID 2611215.
  13. ↑ Chao, J.; Chao, L. (1988). "Rat urinary kallikrein". Methods Enzymol. 163: 128–143. doi:10.1016/0076-6879(88)63014-x. PMID 3070295.
  14. ↑ Geiger, R.; Miska, W. (1988). "Human tissue kallikrein". Methods Enzymol. 163: 102–115. doi:10.1016/0076-6879(88)63012-6. PMID 3237071.
  15. ↑ Bertrand, R.; Derancourt, J.; Kassab, R. (1989). "Selective cleavage at lysine of the 50 kDa-20 kDa connector loop segment of skeletal myosin S-1 by endoproteinase Arg-C". FEBS Lett. 246: 171–176. doi:10.1016/0014-5793(89)80277-7. PMID 2523317.
  16. ↑ Wines, D.R.; Brady, J.M.; Pritchett, D.B.; Roberts, J.L.; MacDonald, R.J. (1989). "Organization and expression of the rat kallikrein gene family". J. Biol. Chem. 264: 7653–7662. PMID 2708383.
  17. ↑ Elmoujahed, A.; Gutman, N.; Brillard, M.; Gauthier, F. (1990). "Substrate specificity of two kallikrein family gene products isolated from the rat submaxillary gland". FEBS Lett. 265: 137–140. doi:10.1016/0014-5793(90)80903-v. PMID 2194829.
  18. ↑ Xiong, W.; Chen, L.-M.; Chao, J. (1990). "Purification and characterization of a kallikrein-like T-kininogenase". J. Biol. Chem. 265: 2822–2827. PMID 2303430.
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