Prostaglandin EP3 receptor

PTGER3
Identifiers
Aliases PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R, EP3-VI, Prostaglandin E receptor 3
External IDs MGI: 97795 HomoloGene: 105703 GeneCards: PTGER3
Targeted by Drug
dinoprostone, dinoprost, sulprostone, treprostinil, U46619[1]
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

5733

19218

Ensembl

ENSG00000050628

ENSMUSG00000040016

UniProt

P43115

P30557

RefSeq (mRNA)

NM_011196

RefSeq (protein)

n/a

Location (UCSC) Chr 1: 70.85 – 71.05 Mb Chr 3: 157.57 – 157.65 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Prostaglandin E2 receptor 3 (EP3) is a prostaglandin receptor, encoded by the PTGER3 gene.[4]

Receptor

The receptor is a member of the G-protein coupled receptor family. It works through the G protein Gi, leading to a decrease in cytosolic cyclic AMP (cAMP). It is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions.

Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.

Variations

Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.[4]

See also

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia - version of the 10/31/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.