POLR2K

POLR2K
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2K, ABC10-alpha, RPABC4, RPB10alpha, RPB12, RPB7.0, hRPB7.0, hsRPB10a, polymerase (RNA) II subunit K
External IDs	MGI: 102725 HomoloGene: 86049 GeneCards: POLR2K
Gene ontology Molecular function • DNA binding • zinc ion binding • RNA polymerase II activity • metal ion binding • RNA polymerase III activity • DNA-directed 5'-3' RNA polymerase activity • RNA polymerase I activity Cellular component • cytosol • nucleoplasm • DNA-directed RNA polymerase I complex • DNA-directed RNA polymerase III complex • DNA-directed RNA polymerase II, core complex • nucleus Biological process • termination of RNA polymerase I transcription • mRNA splicing, via spliceosome • positive regulation of gene expression, epigenetic • gene expression • somatic stem cell population maintenance • regulation of transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • transcription from RNA polymerase II promoter • transcription, DNA-templated • transcription elongation from RNA polymerase I promoter • positive regulation of viral transcription • gene silencing by RNA • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • positive regulation of type I interferon production • transcription from RNA polymerase III promoter • snRNA transcription from RNA polymerase II promoter • fibroblast growth factor receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5440	17749
Ensembl	ENSG00000147669	ENSMUSG00000045996
UniProt	P53803	Q63871
RefSeq (mRNA)	NM_005034	NM_001039368 NM_023127
RefSeq (protein)	NP_005025.1	NP_075616.2
Location (UCSC)	Chr 8: 100.15 – 100.15 Mb	Chr 15: 36.17 – 36.18 Mb
PubMed search	[1]	[2]
Wikidata

DNA-directed RNA polymerases I, II, and III subunit RPABC4 is a protein that in humans is encoded by the POLR2K gene.

This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases.^[3]

Interactions

POLR2K has been shown to interact with POLR2C.^[4]

References

Further reading