POLE2

POLE2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases POLE2, DPE2, polymerase (DNA) epsilon 2, accessory subunit
External IDs MGI: 1197514 HomoloGene: 2015 GeneCards: POLE2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

5427

18974

Ensembl

ENSG00000100479

ENSMUSG00000020974

UniProt

P56282

O54956

RefSeq (mRNA)

NM_001197330
NM_001197331
NM_002692

NM_011133

RefSeq (protein)

NP_001184259.1
NP_001184260.1
NP_002683.2

NP_035263.1

Location (UCSC) Chr 14: 49.64 – 49.69 Mb Chr 12: 69.2 – 69.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.[3][4][5]

Interactions

POLE2 has been shown to interact with SAP18.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Li Y, Asahara H, Patel VS, Zhou S, Linn S (Jan 1998). "Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon". J Biol Chem. 272 (51): 32337–44. doi:10.1074/jbc.272.51.32337. PMID 9405441.
  4. Jokela M, Mäkiniemi M, Lehtonen S, Szpirer C, Hellman U, Syväoja JE (Mar 1998). "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon". Nucleic Acids Res. 26 (3): 730–4. doi:10.1093/nar/26.3.730. PMC 147316Freely accessible. PMID 9443964.
  5. "Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit)".
  6. Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (Mar 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.

Further reading


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