PCDHB5

PCDHB5
Identifiers
Aliases PCDHB5, PCDH-BETA5, protocadherin beta 5
External IDs MGI: 2136745 HomoloGene: 88834 GeneCards: PCDHB5
Orthologs
Species Human Mouse
Entrez

26167

93881

Ensembl

ENSG00000113209

ENSMUSG00000045657

UniProt

Q9Y5E4

n/a

RefSeq (mRNA)

NM_015669

NM_053135

RefSeq (protein)

NP_056484.2

n/a

Location (UCSC) Chr 5: 141.14 – 141.14 Mb Chr 18: 37.41 – 37.41 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Protocadherin beta-5 is a protein that in humans is encoded by the PCDHB5 gene.[3][4]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
  4. 1 2 "Entrez Gene: PCDHB5 protocadherin beta 5".

Further reading


This article is issued from Wikipedia - version of the 6/3/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.