PCDHB3

PCDHB3
Identifiers
Aliases	PCDHB3, PCDH-BETA3, protocadherin beta 3
External IDs	MGI: 2136737 HomoloGene: 115665 GeneCards: PCDHB3
Gene ontology Molecular function • calcium ion binding Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • synapse assembly • cell adhesion • nervous system development • homophilic cell adhesion via plasma membrane adhesion molecules • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56132	93874
Ensembl	ENSG00000113205	ENSMUSG00000045498
UniProt	Q9Y5E6	n/a
RefSeq (mRNA)	NM_018937	NM_053128
RefSeq (protein)	NP_061760.1	n/a
Location (UCSC)	Chr 5: 141.1 – 141.1 Mb	Chr 18: 37.3 – 37.3 Mb
PubMed search	[1]	[2]
Wikidata

Protocadherin beta-3 is a protein that in humans is encoded by the PCDHB3 gene.^[3][4]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.^[4]

References

Further reading