P2RY6

P2RY6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases P2RY6, P2Y6, pyrimidinergic receptor P2Y6
External IDs MGI: 2673874 HomoloGene: 14289 GeneCards: P2RY6
Targeted by Drug
adenosine diphosphate, 1-amino-4-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid[1]
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

5031

233571

Ensembl

ENSG00000171631

ENSMUSG00000048779

UniProt

Q15077

Q9ERK9

RefSeq (mRNA)

NM_183168

RefSeq (protein)

NP_898991.1

Location (UCSC) Chr 11: 73.26 – 73.3 Mb Chr 7: 100.94 – 100.97 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.[4][5]

Function

The product of this gene, P2Y6, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.[5]

See also

References

  1. "Drugs that physically interact with P2Y purinoceptor 6 view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Communi D, Parmentier M, Boeynaems JM (May 1996). "Cloning, functional expression and tissue distribution of the human P2Y6 receptor". Biochemical and Biophysical Research Communications. 222 (2): 303–8. doi:10.1006/bbrc.1996.0739. PMID 8670200.
  5. 1 2 "Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia - version of the 6/28/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.