Nifurzide

Nifurzide
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	A07AX04 (WHO)
Identifiers
IUPAC name 5-Nitro-N′-[(1E,2E)-3-(5-nitro-2-furyl)-2-propen-1-ylidene]-2-thiophenecarbohydrazide
PubChem (CID)	9571044
ChemSpider	7845510
UNII	Z35R6K4C26^Y
KEGG	D07251^Y
Chemical and physical data
Formula	C₁₂H₈N₄O₆S
Molar mass	336.28012 g/mol
3D model (Jmol)	Interactive image
SMILES [O-][N+](=O)c1ccc(o1)/C=C/C=N/NC(=O)c2ccc(s2)[N+](=O)[O-]
InChI InChI=1S/C12H8N4O6S/c17-12(9-4-6-11(23-9)16(20)21)14-13-7-1-2-8-3-5-10(22-8)15(18)19/h1-7H,(H,14,17)/b2-1+,13-7+ Key:IDUMOVRJNBNOTR-BIZLIJPVSA-N
(verify)

Nifurzide is a nitrofuran derivative and intestinal anti-infectious agent active against Escherichia coli.^[1]

References

↑ Delsarte, A; Faway, M; Frère, JM; Coyette, J; Calberg-Bacq, CM; Heinen, E (March 1981). "Nifurzide, a nitrofuran antiinfectious agent: interaction with Escherichia coli cells". Antimicrobial Agents and Chemotherapy. 19 (3): 477–86. doi:10.1128/aac.19.3.477. PMC 181457. PMID 7018391. |access-date= requires |url= (help)

Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07)

Rehydration	Oral rehydration therapy

Intestinal anti-infectives	Antibiotics Amphotericin B Colistin Fidaxomicin Kanamycin Natamycin Neomycin Nystatin Paromomycin Polymyxin B Rifaximin Streptomycin Vancomycin Sulfonamides Phthalylsulfathiazole Succinylsulfathiazole Sulfaguanidine Nitrofuran Nifuroxazide Nifurzide Imidazole Miconazole Arsenical Acetarsol Oxyquinoline Broxyquinoline

Intestinal adsorbents	Charcoal Bismuth Pectin Kaolin Crospovidone Attapulgite Diosmectite

Antipropulsives (opioids)	Opium tincture (laudanum) Codeine Morphine Camphorated opium tincture (paregoric) crosses BBB: Diphenoxylate (Diphenoxylate/atropine) Difenoxin does not cross BBB: Eluxadoline Loperamide

Intestinal anti-inflammatory agents	corticosteroids acting locally Prednisolone Hydrocortisone Prednisone Betamethasone Tixocortol Budesonide Beclometasone antiallergic agents, excluding corticosteroids Cromoglicic acid aminosalicylic acid and similar agents Sulfasalazine Mesalazine Olsalazine Balsalazide

Antidiarrheal micro-organisms	Saccharomyces boulardii

Other antidiarrheals	Albumin tannate Ceratonia Crofelemer Octreotide Racecadotril

This article is issued from Wikipedia - version of the 8/12/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.