Netupitant/palonosetron

Netupitant/palonosetron
Combination of
Netupitant	NK₁ receptor antagonist
Palonosetron	5-HT₃ receptor antagonist
Clinical data
Trade names	Akynzeo
AHFS/Drugs.com	akynzeo
MedlinePlus	a614053
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral
ATC code	A04AA55 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers

Netupitant/palonosetron (trade name Akynzeo) is a fixed dose combination drug for prevention of acute and delayed chemotherapy-induced nausea and vomiting.^[1] Netupitant is an NK₁ receptor antagonist and palonosetron is a 5-HT₃ receptor antagonist.^[2]

Contraindications

Netupitant/palonosetron is contraindicated during pregnancy.^[3]

Adverse effects

The most common side effects are headache and constipation. The overall profile of adverse effects is comparable to that of palonosetron (see Palonosetron#Adverse effects); no common adverse effects can be attributed to netupitant.^[3]

Interactions

Further information: Netupitant § Interactions, and Palonosetron § Interactions

Pharmacology

Further information: Netupitant § Pharmacology, and Palonosetron § Pharmacology

References

↑ "FDA approves Akynzeo for nausea and vomiting associated with cancer chemotherapy". Food and Drug Administration. October 10, 2014.
↑ "Akynzeo: Summary of Product Characteristics" (PDF). European Medicines Agency. Retrieved 12 July 2016.
1 2 Haberfeld, H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag.

Antiemetics (A04)

5-HT₃ serotonin ion channel antagonists	Alosetron Azasetron Bemesetron Cilansetron Clozapine Dazopride Dolasetron Granisetron Lerisetron Metoclopramide Mianserin Mirtazapine Olanzapine Ondansetron Palonosetron (+netupitant) Quetiapine Ramosetron Ricasetron Tropisetron Zatosetron

5-HT serotonin G-protein receptor antagonists	Clozapine Cyproheptadine Hydroxyzine Olanzapine Risperidone Ziprasidone

CB₁ agonists (cannabinoids)	Dronabinol Nabilone Tetrahydrocannabinol (cannabis)

D₂/D₃ antagonists	Alizapride Bromopride Chlorpromazine Clebopride Domperidone Haloperidol Hydroxyzine Itopride Metoclopramide Metopimazine Prochlorperazine Thiethylperazine Trimethobenzamide

H₁ antagonists (antihistamines)	Cyclizine Dimenhydrinate Diphenhydramine Hydroxyzine Meclizine Promethazine

mACh antagonists (anticholinergics)	Atropine Diphenhydramine Hydroxyzine (very mild) Hyoscyamine Scopolamine

NK₁ antagonists	Aprepitant Casopitant Ezlopitant Fosaprepitant Maropitant Netupitant Rolapitant Vestipitant

Others	Cerium oxalate Dexamethasone Lorazepam Midazolam Propofol

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