NPAT (gene)

NPAT

Identifiers

NPAT, E14, E14/p220, nuclear protein, co-activator of histone transcription, nuclear protein, coactivator of histone transcription

External IDs

MGI: 107605 HomoloGene: 1888 GeneCards: NPAT

Gene ontology
Molecular function	• transcription coactivator activity • protein C-terminus binding • protein binding • transcription corepressor activity • protein N-terminus binding
Cellular component	• cytoplasm • Cajal body • nucleus • Gemini of coiled bodies • nucleoplasm
Biological process	• regulation of gene expression • positive regulation of transcription, DNA-templated • cell cycle • regulation of transcription, DNA-templated • regulation of transcription involved in G1/S transition of mitotic cell cycle • transcription, DNA-templated • negative regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4863


244879

Ensembl


ENSG00000149308


ENSMUSG00000033054

UniProt


Q14207


Q8BMA5

RefSeq (mRNA)


NM_002519 NM_001321307


NM_001081152

RefSeq (protein)


NP_002510.2


NP_001074621.1

Location (UCSC)

Chr 11: 108.16 – 108.22 Mb

Chr 9: 53.54 – 53.57 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Protein NPAT also known as nuclear protein of the ATM locus is a protein that in humans is encoded by the NPAT gene.^[3]^[4]

Interactions

NPAT (gene) has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase^[5] and POU2F1.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Imai T, Sugawara T, Nishiyama A, Shimada R, Ohki R, Seki N, Sagara M, Ito H, Yamauchi M, Hori T (Jun 1997). "The structure and organization of the human NPAT gene". Genomics. 42 (3): 388–92. doi:10.1006/geno.1997.4769. PMID 9205109.
↑ "Entrez Gene: NPAT nuclear protein, ataxia-telangiectasia locus".
1 2 Zheng L, Roeder RG, Luo Y (Jul 2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component". Cell. 114 (2): 255–66. doi:10.1016/S0092-8674(03)00552-X. PMID 12887926.

Imai T, Yamauchi M, Seki N, Sugawara T, Saito T, Matsuda Y, Ito H, Nagase T, Nomura N, Hori T (May 1996). "Identification and characterization of a new gene physically linked to the ATM gene". Genome Research. 6 (5): 439–47. doi:10.1101/gr.6.5.439. PMID 8743993.
Byrd PJ, McConville CM, Cooper P, Parkhill J, Stankovic T, McGuire GM, Thick JA, Taylor AM (Jan 1996). "Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia". Human Molecular Genetics. 5 (1): 145–9. doi:10.1093/hmg/5.1.145. PMID 8789452.
Byrd PJ, Cooper PR, Stankovic T, Kullar HS, Watts GD, Robinson PJ, Taylor MR (Nov 1996). "A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies". Human Molecular Genetics. 5 (11): 1785–91. doi:10.1093/hmg/5.11.1785. PMID 8923007.
Zhao J, Dynlacht B, Imai T, Hori T, Harlow E (Feb 1998). "Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry". Genes & Development. 12 (4): 456–61. doi:10.1101/gad.12.4.456. PMC 316526. PMID 9472014.
Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E (Sep 2000). "NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription". Genes & Development. 14 (18): 2283–97. doi:10.1101/gad.827700. PMC 316937. PMID 10995386.
Sagara M, Takeda E, Nishiyama A, Utsumi S, Toyama Y, Yuasa S, Ninomiya Y, Imai T (Dec 2002). "Characterization of functional regions for nuclear localization of NPAT". Journal of Biochemistry. 132 (6): 875–9. doi:10.1093/oxfordjournals.jbchem.a003300. PMID 12473189.
Gao G, Bracken AP, Burkard K, Pasini D, Classon M, Attwooll C, Sagara M, Imai T, Helin K, Zhao J (Apr 2003). "NPAT expression is regulated by E2F and is essential for cell cycle progression". Molecular and Cellular Biology. 23 (8): 2821–33. doi:10.1128/MCB.23.8.2821-2833.2003. PMC 152552. PMID 12665581.
Wei Y, Jin J, Harper JW (May 2003). "The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain". Molecular and Cellular Biology. 23 (10): 3669–80. doi:10.1128/MCB.23.10.3669-3680.2003. PMC 164767. PMID 12724424.
Zheng L, Roeder RG, Luo Y (Jul 2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component". Cell. 114 (2): 255–66. doi:10.1016/S0092-8674(03)00552-X. PMID 12887926.
Ye X, Wei Y, Nalepa G, Harper JW (Dec 2003). "The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells". Molecular and Cellular Biology. 23 (23): 8586–600. doi:10.1128/MCB.23.23.8586-8600.2003. PMC 262656. PMID 14612403.
Wang A, Ikura T, Eto K, Ota MS (Dec 2004). "Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry". Biochemical and Biophysical Research Communications. 325 (4): 1509–16. doi:10.1016/j.bbrc.2004.10.198. PMID 15555599.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Kalla C, Scheuermann MO, Kube I, Schlotter M, Mertens D, Döhner H, Stilgenbauer S, Lichter P (May 2007). "Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B". European Journal of Cancer. 43 (8): 1328–35. doi:10.1016/j.ejca.2007.02.005. PMID 17449237.
Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS (Nov 2007). "The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes". Cancer Research. 67 (21): 10334–42. doi:10.1158/0008-5472.CAN-07-1560. PMID 17974976.

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NPAT (gene)

Interactions

References

Further reading