Mitraphylline

Mitraphylline

Names
IUPAC name Methyl (1'S,3R,4'aS,5'aS,10'aR)-2-hydroxy-1'-methyl-1',4'a,5',5'a,7',8',10',10'a-octahydrospiro[indole-3,6'-pyrano[3,4-f]indolizine]-4'-carboxylate
Identifiers
CAS Number	509-80-8 Y
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL2135897 N
ChemSpider	84977 N
ECHA InfoCard	100.007.370
EC Number	208-106-0
KEGG	C09227 N
PubChem	94160
UNII	1H9SRL2456 N
InChI InChI=1S/C21H24N2O4/c1-12-14-10-23-8-7-21(16-5-3-4-6-17(16)22-20(21)25)18(23)9-13(14)15(11-27-12)19(24)26-2/h3-6,11-14,18H,7-10H2,1-2H3,(H,22,25)/t12-,13-,14+,18-,21+/m0/s1 N Key: JMIAZDVHNCCPDM-DAFCLMLCSA-N N
SMILES C[C@H]1[C@H]2CN3CC[C@]4([C@@H]3C[C@@H]2C(=CO1)C(=O)OC)C5=CC=CC=C5NC4=O
Properties
Chemical formula	C21H24N2O4
Molar mass	368.1736 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Mitraphylline, an oxindole derivative, is an active alkaloid in the leaves of the tree Mitragyna speciosa, commonly known as kratom.^[1] As a non-narcotic constituent, it also occurs to a significant amount in the bark of Uncaria tomentosa (Cat’s Claw) along with a number of isomeric alkaloids.^[2]

Current research is focusing on antiproliferative and cytotoxic effects and its in vivo efficacy to induce apoptosis in human breast cancer, sarcoma as well as lymphoblastic leukaemia cell lines.^{[3][4][5][6][7]}

References