Mitotic catastrophe

Mitotic catastrophe refers to a mechanism of delayed mitotic-linked cell death, a sequence of events resulting from premature or inappropriate entry of cells into mitosis that can be caused by chemical or physical stresses.[1] Mitotic catastrophe is unrelated to programmed cell death or apoptosis and is observed in cells lacking functional apoptotic pathways.[2] It is has been observed following delayed DNA damage induced by ionizing radiation.[3] It can also be triggered by agents influencing the stability of microtubule spindles, various anticancer drugs and mitotic failure caused by defective cell cycle checkpoints.[4] Mitotic catastrophe is the primary mechanism underlying reproductive cell death in cancer cells treated with ionizing radiation.[2]

Not all cells die immediately following abnormal mitosis caused by mitotic catastrophe, but many do. Cells that do not immediately die are likely to create aneuploid cells following subsequent attempts at cell division posing a risk of oncogenesis (i.e. potentially leading to cancer). A very small fraction of these aneuploid cells produced by mitotic catastrophe might later reduce DNA ploidy by reductive division involving meiotic cell division pathways.[5][6][7]

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  1. ↑ Ianzini, F; Mackey, MA (1997). "Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells.". Int J Radiat Biol. 72: 409–421. PMID 9343106.
  2. 1 2 Ianzini, Fiorenza; Mackey, Michael A (2007). "Mitotic Catastrophe". Apoptosis, Senescence, and Cancer. Humana Press. pp. 73–91. ISBN 978-1-58829-527-9.
  3. ↑ Ianzini, F; Mackey, MA (1998). "Delayed induction of DNA strand breaks following mitotic catastrophe occurring as a result of radiation G2 checkpoint abrogation". Mutagenesis. 13: 337–44. PMID 9717169.
  4. ↑ Castedo M; Perfettini JL; Roumier T; Andreau K; Medema R; Kroemer G. (12 April 2004). "Cell death by mitotic catastrophe: a molecular definition". Oncogene. 23: 2825–2837. doi:10.1038/sj.onc.1207528. ISSN 0950-9232. PMID 15077146.
  5. ↑ Prieur-Carrillo, G; Chu, K; Lindqvist, J; Dewey, WC (2003). "Computerized video time-lapse (CVTL) analysis of the fate of giant cells produced by X-irradiating EJ30 human bladder carcinoma cells". Radiat Res. 159 (6): 705–12. PMID 12751952.
  6. ↑ Erenpreisa, J; Kale's, M; Ianzini, F; Kosmacek, EA; Mackey, MA; Emzinsh, D; Craig, MS; Ivanov, A; Illidge, TM (2005). "Segregation of genomes in polyploid tumor cells following mitotic catastrophe". Cell Biol Int. 29 (12): 1005–1011. doi:10.1016/j.cellbi.2005.10.008. PMID 16314119.
  7. ↑ Ianzini, F; Kosmacek, EA; Nelson, ES; Napoli, E; Erenpreisa, J; Kalejs, M; Mackey, MA (2009). "Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe.". 69: 2296–2304. PMID 19258501.
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