MAPKAP1

MAPKAP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3VOQ

Identifiers

MAPKAP1, JC310, MIP1, SIN1, SIN1b, SIN1g, mitogen-activated protein kinase associated protein 1

External IDs

MGI: 2444554 HomoloGene: 11473 GeneCards: MAPKAP1

Gene ontology
Molecular function	• Ras GTPase binding • phosphatidylinositol-3,5-bisphosphate binding • phosphatidylinositol-3,4-bisphosphate binding • phosphatidic acid binding • protein binding • phosphatidylinositol-4,5-bisphosphate binding • protein kinase binding • phosphatidylinositol-3,4,5-trisphosphate binding
Cellular component	• cytoplasm • cytosol • Golgi apparatus • membrane • plasma membrane • cytoplasmic, membrane-bounded vesicle • nucleoplasm • TORC2 complex • cytoplasmic vesicle • nucleus
Biological process	• substantia nigra development • T cell costimulation • negative regulation of Ras protein signal transduction • phosphatidylinositol-mediated signaling
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


79109


227743


ENSG00000119487


ENSMUSG00000038696


Q9BPZ7


Q8BKH7

RefSeq (mRNA)

NM_001006617 NM_001006618 NM_001006619 NM_001006620 NM_001006621
NM_024117


NM_001290625 NM_001290626 NM_177345

RefSeq (protein)

NP_001006618.1 NP_001006619.1 NP_001006620.1 NP_001006621.1 NP_001006622.1
NP_077022.1


NP_001277554.1 NP_001277555.1 NP_796319.1

Location (UCSC)

Chr 9: 125.44 – 125.71 Mb

Chr 2: 34.41 – 34.62 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.^[3]^[4]

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Schroder W, Cloonan N, Bushell G, Sculley T (Sep 2004). "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene". Gene. 339: 17–23. doi:10.1016/j.gene.2004.07.001. PMID 15363842.
1 2 "Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1".

Further reading

Colicelli J, Nicolette C, Birchmeier C, et al. (1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2913–7. doi:10.1073/pnas.88.7.2913. PMC 51350. PMID 1849280.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Schroder W, Bushell G, Sculley T (2005). "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins". Cell. Signal. 17 (6): 761–7. doi:10.1016/j.cellsig.2004.10.015. PMID 15722200.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Cheng J, Zhang D, Kim K, et al. (2005). "Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation". Mol. Cell. Biol. 25 (14): 5955–64. doi:10.1128/MCB.25.14.5955-5964.2005. PMC 1168836. PMID 15988011.
Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Frias MA, Thoreen CC, Jaffe JD, et al. (2006). "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s". Curr. Biol. 16 (18): 1865–70. doi:10.1016/j.cub.2006.08.001. PMID 16919458.
Jacinto E, Facchinetti V, Liu D, et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell. 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. PMID 16962653.
Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes Dev. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC 1619946. PMID 17043309.
Makino C, Sano Y, Shinagawa T, et al. (2007). "Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway". Genes Cells. 11 (11): 1239–51. doi:10.1111/j.1365-2443.2006.01016.x. PMID 17054722.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Schroder WA, Buck M, Cloonan N, et al. (2007). "Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling". Cell. Signal. 19 (6): 1279–89. doi:10.1016/j.cellsig.2007.01.013. PMID 17303383.

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