MAP4K1

Identifiers

MAP4K1, HPK1, mitogen-activated protein kinase kinase kinase kinase 1

External IDs

OMIM: 601983 MGI: 1346882 HomoloGene: 5199 GeneCards: MAP4K1

Gene ontology
Molecular function	• transferase activity • protein kinase activity • MAP kinase kinase kinase kinase activity • protein serine/threonine kinase activity • nucleotide binding • protein binding • ATP binding • kinase activity
Cellular component	• cytoplasm • membrane
Biological process	• protein autophosphorylation • protein phosphorylation • response to stress • cell proliferation • intracellular signal transduction • activation of MAPKKK activity • activation of JUN kinase activity • peptidyl-serine phosphorylation • phosphorylation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


11184


26411

Ensembl


n/a


ENSMUSG00000037337

UniProt


Q92918


P70218

RefSeq (mRNA)


NM_001042600 NM_007181


NM_008279

RefSeq (protein)


NP_001036065.1 NP_009112.1


NP_032305.2

Location (UCSC)

Chr 19: 38.59 – 38.62 Mb

Chr 7: 28.98 – 29 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.^[3] It is also known as HPK1 (Hematopoietic Progenitor Kinase 1).

Interactions

MAP4K1 has been shown to interact with:

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev. 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585.
↑ Tsuji S, Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R, Kiefer F, Kitamura D (Aug 2001). "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1". J. Exp. Med. 194 (4): 529–39. doi:10.1084/jem.194.4.529. PMC 2193495. PMID 11514608.
1 2 3 Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM (Oct 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene. 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. PMID 9788432.
1 2 3 4 Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH (Feb 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Mol. Cell. Biol. 19 (2): 1359–68. PMC 116064. PMID 9891069.
1 2 3 4 5 Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH (Jun 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". J. Biol. Chem. 276 (22): 18908–14. doi:10.1074/jbc.M101485200. PMID 11279207.
↑ Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, Tan TH (Nov 1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. PMID 10567356.
↑ Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene. 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918.
1 2 Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T (Oct 1997). "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. 272 (44): 27804–11. doi:10.1074/jbc.272.44.27804. PMID 9346925.

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