MAK (gene)

MAK
Identifiers
Aliases MAK, RP62, dJ417M14.2, male germ cell associated kinase
External IDs MGI: 96913 HomoloGene: 31344 GeneCards: MAK
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

4117

17152

Ensembl

ENSG00000111837

ENSMUSG00000021363

UniProt

P20794

Q04859

RefSeq (mRNA)

NM_001242385
NM_001242957
NM_005906

NM_001145802
NM_001145803
NM_008547

RefSeq (protein)

NP_001229314.1
NP_001229886.1
NP_005897.1

NP_001139274.1
NP_001139275.1
NP_032573.2

Location (UCSC) Chr 6: 10.76 – 10.84 Mb Chr 13: 41.03 – 41.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase MAK is an enzyme that in humans is encoded by the MAK gene.[3][4]

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Ma AH, Xia L, Desai SJ, Boucher DL, Guan Y, Shih HM, Shi XB, deVere White RW, Chen HW, Tepper CG, Kung HJ (Sep 2006). "Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells". Cancer Res. 66 (17): 8439–47. doi:10.1158/0008-5472.CAN-06-1636. PMID 16951154.
  4. 1 2 "Entrez Gene: MAK male germ cell-associated kinase".

Further reading


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