List of ICD-9 codes 280–289: diseases of the blood and blood-forming organs

4. Diseases of the blood and blood-forming organs (280–289)

Anemia (280–285)

(280) Iron deficiency anemias
- (280.0) Iron deficiency anemia secondary to blood loss (chronic)
- (280.1) Iron deficiency anemia secondary to inadequate dietary iron intake
- (280.8) Other specified iron deficiency anemias
- (280.9) Iron deficiency anemia, unspecified
(281) Other deficiency anemias
- (281.0) pernicious anemia
- (281.2) Anemia, folate deficiency
- (281.3) Other specified megaloblastic anemias, not elsewhere classified
(282) Hereditary hemolytic anemias
- (282.0) Hereditary spherocytosis
- (282.2) G6PD
- (282.5) Sickle-cell trait
- (282.6) Sickle-cell anemia
(283) Acquired hemolytic anemias
- (283.0) Autoimmune hemolytic anemias
  - Warm autoimmune hemolytic anemia
- (283.1) Non-autoimmune hemolytic anemias
- (283.2) Hemoglobinuria due to hemolysis from external causes
  - Paroxysmal nocturnal hemoglobinuria
(284) Aplastic anemia
- (284.0) Constitutional aplastic anemia
  - (284.01) Constitutional red blood cell aplasia
  - (284.09) Other constitutional aplastic anemia
- (284.1) Pancytopenia
- (284.2) Myelophthisis
- (284.8) Other specified aplastic anemias
  - (284.81) Other specified aplastic anemias
  - (284.89) Red cell aplasia
- (284.9) Aplastic anemia unspecified
(285) Other and unspecified anemias
- (285.0) Sideroblastic anemia
- (285.1) Acute posthemorrhagic anemia
- (285.2) Anemia in chronic illness
  - (285.21) Anemia in chronic kidney disease
  - (285.22) Anemia in neoplastic disease
  - (285.29) Anemia of other chronic illness
- (285.3) Antineoplastic chemotherapy induced anemia
- (285.8) Other specified anemias
- (285.9) Anemia unspecified

Coagulation/hemorrhagic (286–287)

(286) Coagulation defects
- (286.0) Haemophilia A
- (286.1) Haemophilia B
- (286.2) Haemophilia C
- (286.3) Congenital deficiency of other clotting factors
  - Factor XIII deficiency
- (286.4) Von Willebrand's disease
- (286.5) Hemorrhagic disorder due to intrinsic anticoagulants
- (286.6) Defibrination syndrome
- (286.7) Acquired coagulation factor deficiency
- (286.9) Coagulation defects, other
(287) Purpura and other hemorrhagic conditions
- (287.0) Allergic purpura
  - Henoch–Schönlein purpura
- (287.3) Thrombocytopenia, primary
  - (287.31) Immune thrombocytopenic purpura
    - Idiopathic thrombocytopenic purpura
- (287.4) Thrombocytopenia, secondary
- (287.9) Hemorrhagic conditions, unspec.

Other (288–289)

(288) Diseases of white blood cells
- (288.0) Leukopenia
- (288.1) Functional disorders of polymorphonuclear neutrophils
- (288.2) Genetic anomalies of leukocytes
- (288.3) Eosinophilia
- (288.4) Hemophagocytic syndromes
- (288.5) Decreased white blood cell count
  - (288.50) Leukocytopenia, unspecified
  - (288.51) Lymphocytopenia
- (288.6) Elevated white blood cell count
  - (288.60) Leukocytosis, unspecified
  - (288.61) Lymphocytosis (symptomatic)
  - (288.62) Leukemoid reaction
  - (288.63) Monocytosis (symptomatic)
  - (288.64) Plasmacytosis
  - (288.65) Basophilia
  - (288.66) Bandemia
- (288.8) Other specified disease of white blood cells
- (288.9) Abnormal white blood cells, unspec.
(289) Other diseases of blood and blood-forming organs
- (289.0) Polycythemia secondary
- (289.1) Chronic lymphadenitis
- (289.2) Nonspecific mesenteric lymphadenitis
- (289.3) Lymphadenitis unspecified except mesenteric
- (289.4) Hypersplenism
- (289.5) Other diseases of spleen
  - (289.50) Disease of spleen unspecified
  - (289.51) Chronic congestive splenomegaly
  - (289.52) Splenic sequestration
  - (289.53) Neutropenic splenomegaly
  - (289.59) Other diseases of spleen
- (289.6) Familial polycythemia
- (289.7) Methemoglobinemia
- (289.8) Other specified diseases of blood and blood-forming organs
  - (289.81) Primary hypercoagulable state
  - (289.82) Secondary hypercoagulable state
  - (289.83) Myelofibrosis
  - (289.84) Heparin-induced thrombocytopenia
  - (289.89) Other specified diseases of blood and blood-forming organs
- (289.9) Unspecified diseases of blood and blood-forming organs

Hereditary	enzymopathy: G6PD glycolysis PK TI HK hemoglobinopathy: Thalassemia alpha beta delta Sickle-cell disease/trait HPFH membrane: Hereditary spherocytosis Minkowski–Chauffard syndrome Hereditary elliptocytosis Southeast Asian ovalocytosis Hereditary stomatocytosis

Acquired	Autoimmune WAHA CAD PCH membrane PNH MAHA TM HUS Drug-induced autoimmune Drug-induced nonautoimmune Hemolytic disease of the newborn

Aplastic
(mostly normo-)

Blood tests

MCV
MCHC
- Normochromic
- Hypochromic

Other

Diseases of clotting (D50–69,74, 280–287)

Coagulation/
coagulopathy

↑

Hyper- coagulability	primary: Antithrombin III deficiency Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden Prothrombin G20210A Sticky platelet syndrome acquired:Thrombocytosis essential DIC Purpura fulminans autoimmune Antiphospholipid

↓

Hypo-
coagulability

Thrombocytopenia	Thrombocytopenic purpura: ITP Evans syndrome TM TTP Upshaw Schulman syndrome Heparin-induced thrombocytopenia May–Hegglin anomaly

Platelet function	adhesion Bernard–Soulier syndrome aggregation Glanzmann's thrombasthenia platelet storage pool deficiency Hermansky–Pudlak syndrome Gray platelet syndrome

Clotting factor	Hemophilia A/VIII B/IX C/XI von Willebrand disease Hypoprothrombinemia/II XIII Dysfibrinogenemia Congenital afibrinogenemia

Lymphatic disease: Congenital lymphatic organ disorders (Q89.0/Q89.2, 759.0/759.2)

Thymus	Thymic hypoplasia DiGeorge syndrome Ectopic thymus

Spleen	Congenital asplenia/hyposplenism Asplenia with cardiovascular anomalies Accessory spleen Polysplenia

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List of ICD-9 codes 280–289: diseases of the blood and blood-forming organs

4. Diseases of the blood and blood-forming organs (280–289)

Anemia (280–285)

Coagulation/hemorrhagic (286–287)

Other (288–289)

See also