|AHFS/Drugs.com||International Drug Names|
|ATC code||L03AX01 (WHO)|
|Chemical and physical data|
|Molar mass||1152.99948 g/mol|
|(what is this?)|
Lentinan is an intravenous anti-tumor polysaccharide isolated from the fruit body of shiitake (Lentinula edodes mycelium (LEM)). Lentinan has been approved as an adjuvant for stomach cancer in Japan since 1985. Lentinan is one of the host-mediated anti-cancer drugs which has been shown to affect host defense immune systems.
Lentinan is a β-1,3 beta-glucan with β-1,6 branching. Molecular weight of lentinan is 500,000 Da. Specific rotation +14-22° (NaOH).
An in vitro experiment showed lentinan stimulated production of white blood cells in the human cell line U937. A pharmacological blend (MC-S) of lentinan, PSK, Ganoderma lucidum and Astragalus propinquus has also been shown to stimulate white blood cell production in vitro.
An in vivo experiment on mice, revealed lentinan is orally active (since clinical use of the drug is administered through an IV).
Lentinan may have been implicated in shiitake mushroom dermatitis.
Formulations containing Lentinan
Lentinex is a formulation featuring lentinan and is approved as a safe novel food in the EU.
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- Isoda N, Eguchi Y, Nukaya H, et al. (2009). "Clinical efficacy of superfine dispersed lentinan (β-1,3-glucan) in patients with hepatocellular carcinoma". Hepatogastroenterology. 56 (90): 437–41. PMID 19579616.
- Shimizu K, Watanabe S, Watanabe S, et al. (2009). "Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer". Hepatogastroenterology. 56 (89): 240–4. PMID 19453066.
- Nakamura, T (1992). "Shiitake (Lentinus edodes) dermatitis". Contact Dermatitis. 27 (2): 65–70. doi:10.1111/j.1600-0536.1992.tb05211.x. PMID 1395630.
- Bao, H.; et al. (2016). "Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal Dectin-1/AMPA receptor signaling pathway". Behavioural Brain Research. doi:10.1016/j.bbr.2016.09.062. PMID 27693847.
- EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2010), "Scientific Opinion on the safety of "Lentinus edodes extract" (Lentinex®) as a Novel Food ingredient" (PDF), EFSA Journal, 7 (8): 1685, doi:10.2903/j.efsa.2010.1685
- Chihara, G. et al. ”Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom)”, Cancer Research (1970),30(11):2776-2781.
- Ina, K. et al. “Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy”, World Journal of Clinical Oncology (2011),2(10):339-343.
- State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, Yunnan, PR China; School of Medicine, Yunnan University,Kunming, Yunnan, PR China., "Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal Dectin-1/AMPA receptor signaling pathway.", Behav Brain Res. 2016 Sep 28;317:263-271. doi: 10.1016/j.bbr.2016.09.062.
- Lentinan effects (antitumor and others)
- Memorial Sloan-Kettering Cancer Center's page for Lentinan.
- About Shiitake (by Solomon P. Wasser, 2005)