- The cathedral of a diocese.
- The major church building (temple) of a monastery corresponding to a conventual church in Western Christianity.
- A large church in a city at which all the faithful of the city gather to celebrate certain important feasts rather than go to their local parish church.
The name derives from the fact that it is (usually) the largest church where all gather together to celebrate the major feast days of the liturgical year. In Russia, it is common for a katholikon to have a smaller church in the basement which can be more easily heated in the winter. A katholikon may have special architectural features in it, such as a kathedra (episcopal throne), or both an esonarthex (inner-narthex) and exonarthex (outer narthex), used for special services such as the Paschal vigil or a lity.
The word katholikon is often translated into English as cathedral rather than assembly and that can cause confusion. In Saint Isaac's Cathedral in Saint Petersburg, Russia, for example, there is a placard in Russian and in English describing the building as having been "кафедральный собор", rendered in English as the "cathedraly cathedral". However an Eastern Orthodox diocese may have several katholikons, only one of which is the bishop's cathedral, other important churches being known as katholicons. The rector of such churches is usually an archpriest.
- Sokolof, Archpriest D. (1917), A Manual of the Orthodox Church's Divine Services, Jordanville NY: Printshop of St. Job of Pochaev (published 2001), p. 50