KIAA0895

KIAA0895 is a human gene that encodes a protein known as KIAA0895 protein or hypothetical protein LOC23366.^[3][4] Other known aliases are OTTHUMP00000206979 and OTTHUMP00000206980.^[5]

Gene

The KIAA0895 gene is located at p14.2 on chromosome 7.

The location of the KIAA0895 gene on chromosome 7

It can be transcribed into 15 transcript variants, which in turn can produce 13 different isoforms of the protein.^[6]

The genomic DNA is 65,976 [base pair]s long,^[3] while the longest mRNA that it produces is 4463 bases long.

Gene Neighborhood

KIAA0895 is surrounded by the following genes on chromosome 7:^[3]

• ELMO1
• AOAH
• HERPUD2
• TBX20

Protein

The longest protein isoform that is produced by the KIAA0895 gene is termed LOC23366 isoform 1 and is 520 amino acids long.^[7]

Regions

LOC23366 contains a protein domain of unknown function called DUF1704.^[8]

It also contains a region of low complexity from position 120 to position 150 in the protein,^[9] and an arginine-rich area from position 12 to position 51.^[10]

Post-translational Modification

The KIAA0895 protein is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout its structure, particularly in the first half of the protein^[11] The predicted phosphorylation sites are shown on the accompanying graph. There are also predicted to be three N-linked glycosylation sites.^[12]

The predicted serine, threonine, and tyrosine phosphorylation sites of the KIAA0895 protein

Expression

KIAA0895 is shown to be expressed at low levels in various tissues throughout the body. It is expressed most highly in the adrenal gland, the bone marrow, and the testis.^[13] It is also found in cancerous tissues, most highly in cervical tumors and bladder carcinoma.

Conservation

KIAA0895 has one paralog in humans known as KIAA0895L.^[14] Orthologs have been found in all mammals, and eukaryotes through T. thermophila.^[15] The full list of organisms in which orthologs have been found is given below.

References