KCNU1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4HPF

Identifiers

Aliases

KCNU1, KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3, potassium calcium-activated channel subfamily U member 1

External IDs

MGI: 1202300 HomoloGene: 7392 GeneCards: KCNU1

Gene ontology
Molecular function	• voltage-gated potassium channel activity • large conductance calcium-activated potassium channel activity • ion channel activity • calcium-activated potassium channel activity • potassium channel activity • voltage-gated ion channel activity
Cellular component	• integral component of membrane • voltage-gated potassium channel complex • plasma membrane • membrane
Biological process	• potassium ion transport • regulation of ion transmembrane transport • ion transport • transmembrane transport • potassium ion transmembrane transport • sperm-egg recognition • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


157855


16532

Ensembl


ENSG00000215262


ENSMUSG00000031576

UniProt


A8MYU2


O54982

RefSeq (mRNA)


NM_001031836


NM_008432

RefSeq (protein)


NP_001027006.2


NP_032458.3

Location (UCSC)

Chr 8: 36.78 – 36.94 Mb

Chr 8: 25.85 – 25.94 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

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Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the K_Ca5.1 protein.^[3]

Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.^[4]^[5]^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K⁺ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
↑ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.". Pharmacol Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.
↑ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K⁺ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554.
↑ Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K⁺ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555.

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Schreiber M, Wei A, Yuan A, et al. (1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes.". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8.". Nature. 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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KCNU1

References

Further reading